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Abstract：
Long non-coding RNA papillary thyroid carcinoma susceptibility candidate 3 (LncRNA PTCSC3) is located on human chromosome 14q13.3. PTCSC3 functions as a tumor suppressor lncRNA to regulate essential cellular processes such as apoptosis, cell proliferation, migration, invasion, angiogenesis, and epithelial-to-mesenchymal transition. PTCSC3 is also involved in the regulation of the Wnt/β-catenin signaling pathway, aerobic glycolysis, and p53 pathways. Downregulation of PTCSC3 has been associated with an increased risk of many tumors such as thyroid, gastric, laryngeal, breast, cervical, oral, lung, and glioma cancers. In addition, dysregulation of PTCSC3 has been reported in non-cancerous disorders notably osteoporosis and periodontitis. However, a number of single nucleotide polymorphisms at PTCSC3 have been linked to a higher risk of human diseases. This literature review summarizes the diagnostic, prognostic, and the clinical value of abnormal expression of PTCSC3 in cancerous and non-cancerous disorders and comprehensively analyzes potential molecular regulatory mechanism related to PTCSC3, which is expected to provide clear guidance for future PTCSC3 research.
摘要：
长链非编码RNA乳头状甲状腺癌易感性候选物3（LncRNAPTCSC3）位于人类染色体14q13.3。PTCSC3作为肿瘤抑制因子lncRNA来调节必要的细胞过程，如细胞凋亡，细胞增殖，迁移,入侵,血管生成,和上皮-间质转化。PTCSC3还参与Wnt/β-catenin信号通路的调节,有氧糖酵解，和p53通路。PTCSC3的下调与许多肿瘤如甲状腺的风险增加有关。胃,喉,乳房,子宫颈,口服,肺，和神经胶质瘤癌症。此外,已经报道PTCSC3的失调在非癌性疾病,特别是骨质疏松症和牙周炎中。然而,许多PTCSC3的单核苷酸多态性与更高的人类疾病风险有关。这篇文献综述总结了诊断，预后，以及PTCSC3异常表达在癌性与非癌性疾病中的临床价值,综合分析与PTCSC3相关的潜在分子调控机制,以期为今后的PTCSC3研究提供明确的指导。
