Abstract：
Aflatoxin contamination in feed is a common problem in broiler chickens. The present systematic review and meta-analysis examined the impact of aflatoxin-contaminated feed and the efficacy of various feed additives on the production performance of broiler chickens fed aflatoxin-contaminated feed (AF-feed). A total of 35 studies comprising 53 AF-feed experiments were selected following PRISMA guidelines. Feed additives included in the analyses were toxins binder (TB), mannan-oligosaccharides (MOS), organic acid (OA), probiotics (PRO), protein supplementation (PROT), phytobiotics (PHY), and additive mixture (MIX). Random effects model and a frequentist network meta-analysis (NMA) were performed to rank the efficacy of feed additives, reported as standardized means difference (SMD) at 95% confidence intervals (95% CI). Overall, broiler chickens fed AF-feed had significantly lower final body weight (BW) (SMD = 198; 95% CI = 198 to 238) and higher feed conversion ratio (SMD = 0.17; 95% CI = 0.13 to 0.21) than control. Treatments with TB, MOS, and PHY improved the BW of birds fed AF-feed (P < 0.05) to be comparable with non-contaminated feed or control. Predictions on final BW from the broiler-fed aflatoxin-contaminated diet were 15% lower than the control diet. Including feed additives in the aflatoxins diet could ameliorate the depressive effect. Remarkably, our network meta-analysis highlighted that TB was the highest-performing additive (P-score = 0.797) to remedy aflatoxicosis. Altogether, several additives, especially TB, are promising to ameliorate aflatoxicosis in broiler chickens, although the efficacy was low regarding the severity of the aflatoxicosis.
摘要：
饲料中的黄曲霉毒素污染是肉鸡常见的问题。本系统综述和荟萃分析研究了黄曲霉毒素污染的饲料和各种饲料添加剂对饲喂黄曲霉毒素污染的饲料（AF-feed）的肉鸡生产性能的影响。根据PRISMA指南选择了总共35项研究，其中包括53项AF补料实验。分析中包括的饲料添加剂是毒素结合剂(TB)，甘露寡糖（MOS），有机酸(OA),益生菌（PRO），蛋白质补充剂（PROT），植物生物（PHY），和添加剂混合物（MIX）。随机效应模型和频率网络荟萃分析（NMA）进行排序的饲料添加剂的功效，以95%置信区间(95%CI)报告为标准化均值差异(SMD)。总的来说,饲喂AF饲料的肉鸡的最终体重（BW）（SMD=198；95％CI=198至238）和饲料转化率（SMD=0.17；95％CI=0.13至0.21）明显低于对照组。结核病治疗，MOS,和PHY提高了饲喂AF饲料的鸟类的BW（P<0.05），与未污染的饲料或对照相当。肉鸡饲喂黄曲霉毒素污染的饮食对最终体重的预测比对照饮食低15％。在黄曲霉毒素日粮中加入饲料添加剂可以改善抑制作用。值得注意的是,我们的网络荟萃分析强调,TB是治疗黄曲霉毒素中毒的最佳添加剂(P分数=0.797).总之,几种添加剂，尤其是结核病，有望改善肉鸡的黄曲霉毒素病，尽管在黄曲霉毒素病的严重程度方面疗效较低。
