Abstract：
Glioblastoma (GBM) is the most aggressive type of glioma (Grade IV). The presence of cytotoxic T lymphocyte (CTLs) has been associated with improved outcomes in patients with GBM, and it is believed that the activation of CTLs by dendritic cells may play a critical role in controlling the growth of GBM. DCs are professional antigen-presenting cells (APC) that orchestrate innate and adaptive anti-GBM immunity. DCs can subsequently differentiate into plasmacytoid DCs (pDC), conventional DC1 (cDC1), conventional (cDC2), and monocyte-derived DCs (moDC) depending on environmental exposure. The different subsets of DCs exhibit varying functional capabilities in antigen presentation and T cell activation in producing an antitumor response. In this review, we focus on recent studies describing the phenotypic and functional characteristics of DC subsets in humans and their respective antitumor immunity and immunotolerance roles in the GBM-associated microenvironment. The critical components of crosstalk between DC subsets that contribute significantly to GBM-specific immune responses are also highlighted in this review with reference to the latest literature. Since DCs could be prime targets for therapeutic intervention, it is worth summarizing the relevance of DC subsets with respect to GBM-associated immunologic tolerance and their therapeutic potential.
摘要：
胶质母细胞瘤（GBM）是最具侵袭性的神经胶质瘤类型（IV级）。细胞毒性T淋巴细胞（CTL）的存在与GBM患者预后的改善有关，并且认为树突状细胞对CTL的激活可能在控制GBM的生长中起关键作用。DC是专业的抗原呈递细胞(APC),其协调先天和适应性抗GBM免疫。DC随后可以分化为浆细胞样DC（pDC），常规DC1(cDC1)，常规(cDC2)，和单核细胞来源的DC（moDC）取决于环境暴露。DC的不同子集在产生抗肿瘤应答中在抗原呈递和T细胞活化方面表现出不同的功能能力。在这次审查中,我们专注于描述人类DC亚群的表型和功能特征以及它们在GBM相关微环境中各自的抗肿瘤免疫和免疫耐受作用的最新研究。在这篇综述中，参考最新文献，还强调了对GBM特异性免疫反应有重要贡献的DC亚群之间的串扰的关键成分。由于DC可能是治疗干预的主要目标，值得总结DC亚群与GBM相关免疫耐受的相关性及其治疗潜力.
