Abstract：
Chronic cough (CC) is a common but poorly understood disease that has a negative impact on quality of life. For years, clinicians have been trying to find the underlying diagnosis and using existing disease models to describe the patients\' illness. This presents a confusing picture of CC. Most patients with CC present with hypersensitivity of the cough reflex, which is characterised by laryngeal paraesthesia and an increased response to the tussive stimuli or an innocuous stimulus that would not trigger coughing in healthy people. Recently, it has been proposed that CC is a unique disease characterised by vagal hypersensitivity that projects to the central nervous system altering responsiveness. The evidence supports the hypothesis that CC is primarily a neurological disorder, consisting of different phenotypes.
摘要：
慢性咳嗽（CC）是一种常见但知之甚少的疾病，对生活质量有负面影响。多年来,临床医生一直试图找到潜在的诊断，并使用现有的疾病模型来描述患者的病情。这呈现了一个令人困惑的CC图片。大多数CC患者表现为咳嗽反射过敏，其特征是喉部感觉异常，对咳嗽刺激或无害刺激的反应增加，不会引发健康人的咳嗽。最近,已经提出CC是一种以迷走神经超敏反应为特征的独特疾病,其投射到中枢神经系统改变反应性。证据支持CC主要是一种神经系统疾病的假设，由不同的表型组成。
