PDF(Pubmed)
Abstract：
Mild intermittent hypoxia initiates progressive augmentation (PA) and ventilatory long-term facilitation (vLTF) in humans. The magnitude of these forms of plasticity might be influenced by anthropometric and physiological variables, as well as protocol elements. However, the impact of many of these variables on the magnitude of respiratory plasticity has not been established in humans. A meta-analysis was completed using anthropometric and physiological variables obtained from 124 participants that completed one of three intermittent hypoxia protocols. Simple correlations between the aggregate variables and the magnitude of PA and vLTF standardized to baseline was completed. Thereafter, the variables correlated to PA or vLTF were input into a multilinear regression equation. Baseline measures of the hypoxic ventilatory response was the sole predictor of PA (R = 0.370, P = 0.012). Similarly, this variable along with the hypoxic burden predicted the magnitude of vLTF (R = 0.546, P < 0.006 for both variables). In addition, the magnitude of PA was strongly correlated to vLTF (R = 0.617, P < 0.001). Anthropometric measures do not predict the magnitude of PA and vLTF in humans. Alternatively, the hypoxic ventilatory response was the sole predictor of PA, and in combination with the hypoxic burden, predicted the magnitude of vLTF. These influences should be considered in the design of mild intermittent hypoxia protocol studies in humans. Moreover, the strong correlation between PA and vLTF suggests that a common mechanistic pathway may have a role in the initiation of these forms of plasticity. KEY POINTS: Mild intermittent hypoxia initiates progressive augmentation (PA) and ventilatory long-term facilitation (vLTF) in humans. Many of the anthropometric and physiological variables that could impact the magnitude of these forms of plasticity are unknown. Anthropometric and physiological variables were measured from a total of 124 participants that completed one of three distinct intermittent hypoxia protocols. The variables correlated to PA or vLTF were input into a multilinear regression analysis. The hypoxic ventilatory response was the sole predictor of PA, while this variable in addition to the average hypoxic burden predicted the magnitude of vLTF. A strong correlation between PA and vLTF was also revealed. These influences should be considered in the design of mild intermittent hypoxia protocol studies in humans. Moreover, the strong correlation between PA and vLTF suggests that a common mechanistic pathway may have a role in the initiation of these forms of plasticity.
摘要：
轻度间歇性缺氧会引发人类的进行性增强（PA）和通气长期促进（vLTF）。这些可塑性形式的大小可能会受到人体测量和生理变量的影响，以及协议元素。然而,许多这些变量对呼吸可塑性大小的影响尚未在人类中确定。使用从124名参与者获得的人体测量和生理变量完成了荟萃分析，这些参与者完成了三种间歇性缺氧方案之一。完成了聚合变量与标准化至基线的PA和vLTF的大小之间的简单相关性。此后,将与PA或vLTF相关的变量输入到多元线性回归方程中.低氧通气反应的基线测量是PA的唯一预测因子（R=0.370，P=0.012）。同样，该变量与低氧负荷一起预测了vLTF的大小(两个变量的R=0.546,P<0.006).此外,PA的大小与vLTF密切相关（R=0.617，P<0.001）。人体测量不能预测人体内PA和vLTF的大小。或者，低氧通气反应是PA的唯一预测因子，结合缺氧负担，预测了vLTF的大小。在人类轻度间歇性缺氧方案研究的设计中应考虑这些影响。此外，PA和vLTF之间的强相关性表明，共同的机制途径可能在这些形式的可塑性的启动中起作用。关键点：轻度间歇性缺氧可引发人类进行性增强（PA）和长期通气促进（vLTF）。可能影响这些可塑性形式的大小的许多人体测量和生理变量是未知的。从总共124名参与者中测量了人体测量和生理变量，这些参与者完成了三种不同的间歇性缺氧方案之一。将与PA或vLTF相关的变量输入到多元线性回归分析中。低氧通气反应是PA的唯一预测因子，而这个变量除了平均缺氧负荷外还预测了vLTF的大小。还揭示了PA和vLTF之间的强相关性。在人类轻度间歇性缺氧方案研究的设计中应考虑这些影响。此外，PA和vLTF之间的强相关性表明，共同的机制途径可能在这些形式的可塑性的启动中起作用。
