A 13 year-old Chinese female patient infected with MDR HIV strains showed a decrease in viral load (from 4.48 log10 to 1.73 log10) and an increase in CD4 + T cells (from 15 to 308 cells/µl) after 12 months of treatment with an ABT-based antiretroviral regimen. The child showed no relevant drug-related adverse reactions.
The case reported here could suggest that an ABT-based antiretroviral therapy might be beneficial and without relevant toxicity in children with MDR HIV. Infectiologists specializing in managing HIV should be prepared to manage an increasing number of children with MDR HIV. ABT might be a new treatment option for MDR HIV infection in children.
方法:一名13岁的中国女性患者感染了MDRHIV病毒株,在使用基于ABT的抗逆转录病毒方案治疗12个月后,病毒载量降低(从4.48log10降低至1.73log10),CD4+T细胞增加(从15至308细胞/μl)。患儿未出现与药物相关的不良反应。
结论:本文报道的病例可能表明,基于ABT的抗逆转录病毒疗法可能对患有MDRHIV的儿童有益,并且没有相关毒性。专门管理艾滋病毒的传染病学家应该准备好管理越来越多的患有MDR艾滋病毒的儿童。ABT可能是儿童MDRHIV感染的新治疗选择。