关键词: Lactose intolerance lactase gene lactose intolerance treatment lactose metabolism single nucleotide polymorphism

Mesh : Humans Animals Lactose Intolerance / diagnosis Lactase / genetics Polymorphism, Single Nucleotide / genetics Diet Milk / adverse effects

来  源:   DOI:10.1080/27697061.2023.2251557

Abstract:
The majority (about 70%) of the world\'s population suffers from lactose intolerance. Lactose intolerance leads to long-term discomfort when consuming milk and dairy products, and hence, to their avoidance. Consequently, the intake of important nutrients is reduced, which potentially has a negative impact on the overall health. Knowing the condition - lactose intolerance - will prevent people from unnecessarily restricting dairy products in their diets. In this study, lactose synthesis and catabolism in the human body are presented, also the types of lactose intolerance, as well as the methods of diagnosing this condition, are discussed. Special attention is paid to the genetic causes of this discomfort and to the tests that can be performed. Solutions for the treatment of lactose intolerance have also been proposed, both up-to-date and easily applicable, as well as future developments.
This review highlights the lactose pathway – from the mammary gland production to recipient gut hydrolysis.Lactose intolerance associated SNPs known so far are presented and discussed.Advice for people with lactose intolerance is presented in the form of possible treatments and healthy feeding behaviors.
摘要:
世界上大多数人(约70%)患有乳糖不耐受症。在食用牛奶和乳制品时,乳糖不耐受会导致长期不适,因此,他们的回避。因此,重要营养素的摄入量减少,这可能会对整体健康产生负面影响。了解这种情况-乳糖不耐受-将防止人们不必要地限制饮食中的乳制品。在这项研究中,人体内的乳糖合成和分解代谢,还有乳糖不耐受的类型,以及诊断这种情况的方法,正在讨论。特别注意这种不适的遗传原因以及可以进行的测试。还提出了治疗乳糖不耐受的解决方案,既最新又易于应用,以及未来的发展。
这篇综述强调了乳糖途径-从乳腺生产到受体肠道水解。介绍和讨论了迄今为止已知的乳糖不耐受相关的SNP。对乳糖不耐受患者的建议以可能的治疗方法和健康的喂养行为的形式呈现。
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