PDF(Pubmed)
Abstract：
UNASSIGNED: Retinal artery occlusion (RAO) is an ophthalmic emergency that can lead to poor visual outcomes and is associated with an increased risk of stroke and cardiovascular events. Wide-field swept-source OCT-A (WF SS-OCTA) can provide quick and non-invasive angiographic information with a wide field of view. Here, we looked for associations between OCT-A vascular imaging metrics and vision in RAO patients.
UNASSIGNED: Patients with diagnoses of central (CRAO) or branched retinal artery occlusion (BRAO) were included. 6mm × 6mm Angio and 15mm × 15mm AngioPlex Montage OCT-A images were obtained for both eyes in each patient using Zeiss Plex Elite 9000 WF SS-OCTA device. Each 6mm × 6mm image was divided into nine Early Treatment Diabetic Retinopathy Study (ETDRS) subfields. Non-perfusion area (NPA) was manually measured using 15mm × 15mm images. A linear regression model was utilized to identify correlation between imaging metrics and vision. P-values less than 0.05 were considered as statistically significant.
UNASSIGNED: Twenty-five subjects were included. For RAO eyes, there was a statistically significant inverse correlation between retinal thickness as well as superficial capillary plexus (SCP) vessel density (VD) and vision. An inverse correlation was found between deep capillary plexus (DCP) VD and vision without statistical significance. There was a positive correlation between choroidal thickness as well as choroidal volume and vision without statistical significance. No significant correlation was found between the metrics and vision in contralateral eyes. For NPA and vision, no significant correlation was identified.
UNASSIGNED: This is the first study to investigate the utility of WF SS-OCTA in RAO and to demonstrate correlations between retinal vascular imaging metrics and visual outcomes. The results of this study provide a basis to understand the structural changes involved in vision in RAO and may guide management of RAO and prevention of cerebral stroke and cardiovascular accidents.
UNASSIGNED: Patients with diagnoses of central (CRAO) or branched retinal artery occlusion (BRAO) were included. 6mm × 6mm Angio and 15mm × 15mm AngioPlex Montage OCT-A images were obtained for both eyes in each patient using Zeiss Plex Elite 9000 WF SS-OCTA device. Each 6mm × 6mm image was divided into nine Early Treatment Diabetic Retinopathy Study (ETDRS) subfields. Non-perfusion area (NPA) was manually measured using 15mm × 15mm images. A linear regression model was utilized to identify correlation between imaging metrics and vision. P-values less than 0.05 were considered as statistically significant.
UNASSIGNED: Twenty-five subjects were included. For RAO eyes, there was a statistically significant inverse correlation between retinal thickness as well as superficial capillary plexus (SCP) vessel density (VD) and vision. An inverse correlation was found between deep capillary plexus (DCP) VD and vision without statistical significance. There was a positive correlation between choroidal thickness as well as choroidal volume and vision without statistical significance. No significant correlation was found between the metrics and vision in contralateral eyes. For NPA and vision, no significant correlation was identified.
UNASSIGNED: This is the first study to investigate the utility of WF SS-OCTA in RAO and to demonstrate correlations between retinal vascular imaging metrics and visual outcomes. The results of this study provide a basis to understand the structural changes involved in vision in RAO and may guide management of RAO and prevention of cerebral stroke and cardiovascular accidents.
摘要：
■视网膜动脉闭塞（RAO）是一种眼科急症，可导致视力不良，并与中风和心血管事件的风险增加有关。宽场扫频源OCT-A(WFSS-OCTA)可提供具有宽视场的快速和非侵入性血管造影信息。这里,我们在RAO患者中寻找OCT-A血管成像指标与视力之间的关联.
■包括诊断为中央（CRAO）或分支视网膜动脉阻塞（BRAO）的患者。使用ZeissPlexElite9000WFSS-OCTA装置获得每位患者双眼的6mm×6mm血管造影和15mm×15mm血管造影蒙太奇OCT-A图像。每张6mm×6mm图像分为9个早期治疗糖尿病视网膜病变研究（ETDRS）子域。使用15mm×15mm图像手动测量非灌注面积(NPA)。利用线性回归模型来识别成像指标和视觉之间的相关性。P值小于0.05被认为具有统计学意义。
■包括25名受试者。对于RAO的眼睛，视网膜厚度以及浅表毛细血管丛（SCP）血管密度（VD）与视力之间存在统计学上的显着负相关。深毛细血管丛（DCP）VD与视力呈负相关，无统计学意义。脉络膜厚度、脉络膜体积与视力呈正相关，无统计学意义。在对侧眼睛中，指标与视力之间没有发现显着相关性。对于NPA和愿景，没有发现显著的相关性.
■这是第一项研究，旨在研究WFSS-OCTA在RAO中的实用性，并证明视网膜血管成像指标与视觉结果之间的相关性。这项研究的结果为了解RAO中视力的结构变化提供了基础，并可能指导RAO的管理和预防脑卒中和心血管事故。
■包括诊断为中央（CRAO）或分支视网膜动脉阻塞（BRAO）的患者。使用ZeissPlexElite9000WFSS-OCTA装置获得每位患者双眼的6mm×6mm血管造影和15mm×15mm血管造影蒙太奇OCT-A图像。每张6mm×6mm图像分为9个早期治疗糖尿病视网膜病变研究（ETDRS）子域。使用15mm×15mm图像手动测量非灌注面积(NPA)。利用线性回归模型来识别成像指标和视觉之间的相关性。P值小于0.05被认为具有统计学意义。
■包括25名受试者。对于RAO的眼睛，视网膜厚度以及浅表毛细血管丛（SCP）血管密度（VD）与视力之间存在统计学上的显着负相关。深毛细血管丛（DCP）VD与视力呈负相关，无统计学意义。脉络膜厚度、脉络膜体积与视力呈正相关，无统计学意义。在对侧眼睛中，指标与视力之间没有发现显着相关性。对于NPA和愿景，没有发现显著的相关性.
■这是第一项研究，旨在研究WFSS-OCTA在RAO中的实用性，并证明视网膜血管成像指标与视觉结果之间的相关性。这项研究的结果为了解RAO中视力的结构变化提供了基础，并可能指导RAO的管理和预防脑卒中和心血管事故。
