PDF(Pubmed)
Abstract：
Introduction: Odontogenic tumors encompass a heterogeneous group of lesions that range from hamartomatous lesions to malignancy. Considerable variation in histologic presentation can mislead their accurate diagnosis and categorization. Ameloblastoma is generally well understood and is easy to diagnose but there has been a constant change in the classification systems ever since Broca classified odontogenic tumors in the year 1867. Over the years, it has been modified by the World Health Organization with many additions and omissions. This dynamic change is based on the result and conclusions of molecular and genetic studies with the last modification in 2017. Case Report: We present two cases of females aged 32 and 60 years who reported with facial swellings, revealed the presence of distinct histopathological findings and were diagnosed as ameloblastoma with dentinoid or adenoid ameloblastoma. Literature search revealed dearth of distinct forms of ameloblastoma that show the formation of duct like structures and dentinoid. Conclusion: It is interesting to highlight such cases as the biological behavior is still unexplored due to paucity of relevant studies and follow up of patients. Understanding the pathogenesis and the histopathological characteristics of the newer entities will enable the prompt diagnosis, treatment plan and expanding the spectrum of the lesions.
UNASSIGNED: The online version contains supplementary material available at 10.1007/s12070-023-03534-6.
UNASSIGNED: The online version contains supplementary material available at 10.1007/s12070-023-03534-6.
摘要：
简介：牙源性肿瘤包括一组异质性病变，范围从错构瘤性病变到恶性肿瘤。组织学表现的显着变化可能会误导其准确的诊断和分类。成釉细胞瘤通常很容易理解并且易于诊断，但是自从Broca在1867年对牙源性肿瘤进行分类以来，分类系统一直在变化。多年来,它已被世界卫生组织修改，有许多补充和遗漏。这种动态变化是基于分子和遗传研究的结果和结论，最后一次修改是在2017年。病例报告：我们介绍了2例32岁和60岁女性报告面部肿胀，显示存在明显的组织病理学发现，并被诊断为成釉细胞瘤伴有牙样或腺样成釉细胞瘤。文献检索显示缺乏不同形式的成釉细胞瘤，这些成釉细胞瘤显示形成导管样结构和牙质。结论：由于缺乏相关研究和对患者的随访，生物学行为仍未被探索，因此强调此类病例很有趣。了解新实体的发病机制和组织病理学特征将有助于及时诊断，治疗计划和扩大病变范围。
■在线版本包含补充材料，可在10.1007/s12070-023-03534-6获得。
■在线版本包含补充材料，可在10.1007/s12070-023-03534-6获得。
