PDF(Pubmed)
Abstract：
The detection of androgen receptors within Juvenile Nasopharyngeal Angiofibroma (JNA) has prompted investigation of the role of Flutamide. The aim of this review is to evaluate Flutamide as a possible neo-adjuvant treatment for JNA. Literature searches were conducted using MEDLINE, EMBASE and Web of Science. The Joanna Briggs Institute (JBI) checklist was used to assess risk of bias. The Oxford Centre of Evidence-Based Medicine (OCEBM) Levels of Evidence was used to stratify the evidence level. Literature searches were conducted using MEDLINE, EMBASE and Web of Science. Flutamide as neo-adjuvant treatment potentially causes a reduction in JNA tumor volume by ≥ 25%. Based on the current limited evidence, Flutamide has a limited role in JNA management and further research is required. Its utilization should only follow discussion with the patient, their families, and within the multidisciplinary team.
摘要：
青少年鼻咽血管纤维瘤（JNA）中雄激素受体的检测促使研究氟他胺的作用。这篇综述的目的是评估氟他胺作为JNA新辅助治疗的可能。使用MEDLINE进行文献检索，EMBASE和WebofScience。乔安娜·布里格斯研究所(JBI)的清单被用来评估偏见的风险。牛津循证医学中心（OCEBM）证据级别用于对证据级别进行分层。使用MEDLINE进行文献检索，EMBASE和WebofScience。氟他胺作为新辅助治疗可能导致JNA肿瘤体积减少≥25%。根据目前有限的证据,氟他胺在JNA管理中的作用有限，需要进一步研究。它的使用应仅在与患者讨论之后，他们的家人,在多学科团队中。
