PDF(Pubmed)
Abstract：
Larynx is an uncommon extranodal site for non-Hodgkin lymphoma (NHL). Anaplastic lymphoma kinase (ALK)-positive B-cell lymphoma is a rare and aggressive form of NHL. A 19-year-old male presented to the ENT department with globus sensation, hoarseness, cervical lymphadenopathy and weight loss. A 70-degree rigid endoscopic examination of the larynx showed a vascular, irregular, submucosal mass arising from the right aryepiglottic fold causing near complete obstruction of the laryngeal airway. PET-CT showed hypermetabolic lesions in the supraglottis, cervical lymph nodes, cervical spine, ribs and abdominal lymph nodes. Biopsy was taken from the supraglottic mass as well as the enlarged cervical lymph nodes, which revealed ALK-positive large B-cell NHL. In this report, we present a rare case of ALK-positive large B-cell NHL of the larynx, discussing its clinical, radiological and pathological features. A limited review of literature is also presented. There is a need to develop a database for the description of lymphomas affecting the larynx and this case report adds to the existing knowledge of this rare entity.
摘要：
喉是非霍奇金淋巴瘤（NHL）的罕见结外部位。间变性淋巴瘤激酶（ALK）阳性B细胞淋巴瘤是NHL的一种罕见且侵袭性形式。一名19岁的男性带着球状的感觉来到耳鼻喉科，声音嘶哑,颈淋巴结肿大和体重减轻。喉部70度刚性内窥镜检查显示血管，不规则,由右臂会厌褶皱引起的粘膜下肿块，导致喉气道几乎完全阻塞。PET-CT显示声门上的高代谢病变，颈部淋巴结,颈椎,肋骨和腹部淋巴结。对声门上肿块以及增大的颈部淋巴结进行活检，显示ALK阳性的大B细胞NHL。在这份报告中,我们提出了一个罕见的情况下，ALK阳性大B细胞的喉NHL，讨论它的临床，放射学和病理学特征。还介绍了有限的文献综述。有必要开发一个数据库来描述影响喉的淋巴瘤，并且该病例报告增加了对这种罕见实体的现有知识。
