PDF(Pubmed)
Abstract：
Clostridioides difficile infection (CDI) is the leading cause of healthcare-associated diarrhea. This infection can particularly affect older adults, the most susceptible to CDI. Currently, the standard therapeutic measure is antibiotic therapy, which in turn increases the risk of recurrence of the infection by its collateral damage to the patient\'s microbiota. Probiotics are live microorganisms capable of maintaining balance in the intestinal microbiota. This study aims to perform an integrative review of the protective benefit of probiotics in CDI and diarrhea associated with C. difficile. The PubMed, Scopus, and Web of Science databases, the 10-year time cutoff, and the Prism Flow diagram were used for data collection. We observed no consensus among the studies; however, three of the seven evaluated studies demonstrated that the use of probiotics in older adults could contribute to reducing the incidence of hospital-onset CDI. We also found that the studies evaluated a wide variety of microorganisms, particularly Saccharomyces boulardii, associated with beneficial effects. More research is needed to understand the successful use of probiotics in the prevention of CDI in hospitalized older adults receiving antibiotics.
摘要：
艰难梭菌感染（CDI）是医疗保健相关性腹泻的主要原因。这种感染尤其会影响老年人，最容易受到CDI的影响。目前,标准的治疗措施是抗生素治疗，这反过来又增加了其对患者的微生物群的附带损害感染复发的风险。益生菌是能够维持肠道微生物群平衡的活微生物。这项研究旨在对益生菌在CDI和艰难梭菌相关腹泻中的保护益处进行综合审查。PubMed,Scopus,和WebofScience数据库,十年的时间截止，和棱镜流程图用于数据收集。我们观察到研究之间没有达成共识；然而，7项评估研究中的3项表明,在老年人中使用益生菌有助于降低住院期CDI的发生率.我们还发现，这些研究评估了各种各样的微生物，尤其是布拉氏酵母菌,与有益效果相关。需要更多的研究来了解益生菌在接受抗生素治疗的住院老年人中预防CDI的成功使用。
