PDF(Pubmed)
Abstract：
Few case reports describe metastatic prostate cancer to the thyroid cartilage. While earlier reports identified the metastatic lesions upon developing symptoms, more recent ones have detected them via prostate-specific membrane antigen positron emission tomography (PSMA PET). Herein, we report the case of a patient with metastatic castrate-resistant prostate cancer and a PSMA PET-detected lesion in the thyroid cartilage. Over the course of 2 years, he received multiple lines of chemotherapy and hormonal therapy, and his overall disease status fluctuated - some nodal and bony metastases resolved while others appeared anew. His thyroid cartilage lesion, however, slowly progressed in a consistent fashion with increasing uptake on successive PSMA PET images. Apart from mild dysphonia, the patient remained to be asymptomatic from this lesion, and no local therapies were used. To our knowledge, this is the first close follow-up of prostate cancer metastatic to the thyroid cartilage, shedding light on the course of such lesions and helping answer management-related questions, which are particularly relevant as more occult metastases are discovered in the PSMA PET era.
摘要：
很少有病例报告描述转移性前列腺癌到甲状腺软骨。虽然早期的报告在出现症状时确定了转移性病变，最近的研究已经通过前列腺特异性膜抗原正电子发射断层扫描（PSMAPET）检测到它们。在这里，我们报道了一例转移性去势抵抗性前列腺癌患者,并在甲状软骨中检测到PSMAPET病变.在两年的时间里，他接受了多种化疗和激素治疗，他的整体疾病状态波动-一些淋巴结和骨转移消退，而另一些则重新出现。他的甲状软骨损伤,然而,在连续的PSMAPET图像上随着摄取的增加而以一致的方式缓慢进展。除了轻度发音障碍,患者从这个病变中仍然无症状，没有使用局部疗法。据我们所知,这是前列腺癌转移到甲状腺软骨的首次密切随访，阐明此类病变的病程，并帮助回答与管理相关的问题，这与PSMAPET时代发现的隐匿性转移特别相关。
