PDF(Pubmed)
Abstract：
Metabolic-associated fatty liver disease (MAFLD) and its potential impact on the severity of COVID-19 have gained significant attention during the pandemic. This review aimed to explore the genetic determinants associated with MAFLD, previously recognized as non-alcoholic fatty liver disease (NAFLD), and their potential influence on COVID-19 outcomes. Various genetic polymorphisms, including PNPLA3 (rs738409), GCKR (rs780094), TM6SF2 (rs58542926), and LYPLAL1 (rs12137855), have been investigated in relation to MAFLD susceptibility and progression. Genome-wide association studies and meta-analyses have revealed associations between these genetic variants and MAFLD risk, as well as their effects on lipid metabolism, glucose regulation, and liver function. Furthermore, emerging evidence suggests a possible connection between these MAFLD-associated polymorphisms and the severity of COVID-19. Studies exploring the association between indicated genetic variants and COVID-19 outcomes have shown conflicting results. Some studies observed a potential protective effect of certain variants against severe COVID-19, while others reported no significant associations. This review highlights the importance of understanding the genetic determinants of MAFLD and its potential implications for COVID-19 outcomes. Further research is needed to elucidate the precise mechanisms linking these genetic variants to disease severity and to develop gene profiling tools for the early prediction of COVID-19 outcomes. If confirmed as determinants of disease severity, these genetic polymorphisms could aid in the identification of high-risk individuals and in improving the management of COVID-19.
摘要：
代谢相关脂肪性肝病（MAFLD）及其对COVID-19严重程度的潜在影响在大流行期间引起了广泛关注。这篇综述旨在探讨与MAFLD相关的遗传决定因素，以前被认为是非酒精性脂肪性肝病（NAFLD），以及它们对COVID-19结局的潜在影响。各种遗传多态性，包括PNPLA3(RS738409)，GCKR(rs780094),TM6SF2(rs58542926),和LYPLAL1(rs12137855)，已对MAFLD易感性和进展进行了调查。全基因组关联研究和荟萃分析揭示了这些遗传变异与MAFLD风险之间的关联，以及它们对脂质代谢的影响，葡萄糖调节，和肝功能。此外，新出现的证据表明，这些MAFLD相关多态性与COVID-19的严重程度之间可能存在联系。探索指示的遗传变异与COVID-19结果之间关联的研究显示出相互矛盾的结果。一些研究观察到某些变体对严重COVID-19具有潜在的保护作用，而另一些研究报告没有显着关联。这篇综述强调了了解MAFLD的遗传决定因素及其对COVID-19结局的潜在影响的重要性。需要进一步的研究来阐明将这些遗传变异与疾病严重程度联系起来的确切机制，并开发用于早期预测COVID-19结果的基因谱分析工具。如果被确认为疾病严重程度的决定因素，这些遗传多态性有助于识别高危个体,并有助于改善COVID-19的管理.
