PDF(Pubmed)
Abstract：
Due to the rising demand for supplements targeting cognitive enhancement and dry eye together with the health benefits of anthocyanins, we have developed a functional soup containing an anthocyanin-rich functional ingredient, or \"Anthaplex,\" and assessed the effects on cognitive function and eye dryness together with the possible mechanisms. A total of 69 male and female health volunteers were randomized and divided into placebo, D2, and D4 groups. All subjects consumed 120 mL of placebo or functional soup containing \"Anthaplex\" either at 2 or 4 g per serving per day within 5 min in the morning for eight weeks. The cognitive function, working memory, dry eye, AChE, MAO, MAO-A, MAO-B, and GABA-T activities, BDNF, HAC, HDAC, and DNMT activities, pH, and amount of lactic acid-producing bacteria, particularly Lactobacillus and Bifidobacterium spp. in feces, were determined before intervention and after eight weeks of consumption. Subjects who consumed the \"Anthaplex\" soup had improved cognitive function, working memory, eye dryness, histone acetylation, ACh E suppression, and BDNF with increased Bifidobacterium spp. but decreased pH in feces. These data suggest that \"Anthaplex\" improves cognitive function and eye dryness via the modulations of the histone acetylation process, gut microbiome, and cholinergic function.
摘要：
由于对针对认知增强和干眼症的补充剂以及花青素的健康益处的需求不断增长，我们开发了一种含有富含花青素的功能性成分的功能性汤，或\"Anthaplex,并评估了对认知功能和眼睛干燥的影响以及可能的机制。共有69名男性和女性健康志愿者被随机分为安慰剂，D2和D4组。所有受试者在早上5分钟内每天服用2或4克，每天服用120毫升安慰剂或含有“Anthaplex”的功能汤，持续八周。认知功能，工作记忆,干眼症,AChE,MAO,MAO-A,MAO-B,和GABA-T活动，BDNF,HAC,HDAC,和DNMT活动，pH值,和产乳酸细菌的数量，特别是乳酸菌和双歧杆菌属。在粪便中，在干预前和服用八周后确定。食用“Anthaplex”汤的受试者认知功能得到改善，工作记忆,眼睛干燥，组蛋白乙酰化，AChE抑制,和BDNF与双歧杆菌属物种增加。但粪便中的pH值降低。这些数据表明，“Anthaplex”通过组蛋白乙酰化过程的调节改善认知功能和眼睛干燥，肠道微生物组，和胆碱能功能。
