PDF(Pubmed)
Abstract：
Parabacteroides levels are reported to be low in obese individuals, and this genus has shown an anti-obesity capacity in animal studies. Nevertheless, the relationship between Parabacteroides and obesity in different subpopulations, e.g., with respect to age and sex, and its association with subsequent weight change have rarely been explored. The cross-sectional associations of Parabacteroides genus- and species-level OTU abundance with obesity were explored in the Guangdong Gut Microbiome Project (GGMP), which included 5843 adults, and replicated in the Guangzhou Nutrition and Health Study (GNSH), which included 1637 individuals. Furthermore, we assessed the prospective associations of Parabacteroides and its main OTUs\' abundance with the subsequent changes in body mass index (BMI) in the GNSH. We found that Parabacteroides was inversely associated with obesity among females and participants aged 40-69 years in the GGMP and the replicated cohort in the GNSH. After a 3-year follow-up, there was no significant correlation between Parabacteroides and the subsequent changes in BMI. However, Seq4172 (P. johnsonii) showed a negative correlation with subsequent BMI changes in the female and middle-aged (40-69 years) subpopulations. Overall, our results indicate that Parabacteroides have an inverse relationship with obesity and that Seq4172 (P. johnsonii) have a negative association with subsequent changes in BMI among females and middle-aged populations in perspective analyses.
摘要：
据报道，肥胖个体的副杆菌水平较低，该属在动物研究中显示出抗肥胖能力。然而，副杆菌属与不同亚群肥胖的关系,例如，关于年龄和性别，及其与随后体重变化的关系很少被探索。在广东肠道微生物组项目（GGMP）中探索了副杆菌属和物种级OTU丰度与肥胖的横截面关联，其中包括5843名成年人，并在广州营养与健康研究(GNSH)中复制，其中包括1637个人。此外，我们评估了副杆菌及其主要OTU丰度与随后的GNSH体重指数(BMI)变化的前瞻性关联。我们发现，在GGMP和GNSH的重复队列中，女性和40-69岁的参与者中，副杆菌属与肥胖呈负相关。经过3年的随访,副杆菌与随后的BMI变化之间没有显着相关性。然而,Seq4172(P.johnsonii）与女性和中年（40-69岁）亚群随后的BMI变化呈负相关。总的来说,我们的结果表明，副杆菌与肥胖呈负相关，Seq4172(P.johnsonii）在透视分析中与女性和中年人群的BMI随后变化呈负相关。
