PDF(Pubmed)
Abstract：
The Mild Behavioral Impairment (MBI) concept was developed to determine whether late-onset persistent neuropsychiatric symptoms (NPSs) may be early manifestations of cognitive decline. Our study aims to investigate the prevalence and differentiating features of MBI with respect to major neurocognitive disorders (MNDs) and primary psychiatric disorders (PPDs). A total of 144 elderly patients who were referred to our psychogeriatric outpatient service were recruited. The severity of mental illness was evaluated by means of the Clinical Global Impression Severity scale, the severity of psychopathology was evaluated by means of the Brief Psychiatric Rating Scale (BPRS), and overall functioning was evaluated by means of the Global Assessment of Functioning scale. The sample included 73 (50.6%) patients with PPDs, 40 (27.8%) patients with MBI, and 31 (21.5%) patients with MNDs. Patients with MNDs reported the greatest severity of mental illness, the highest BPRS Total, Psychosis, Activation, and Negative Symptom scores, and the lowest functioning. Patients with MBI and PPDs had comparable levels of severity of mental illness and overall functioning, but MBI patients reported higher BPRS Total and Negative Symptom scores than PPD patients. Patients with MBI frequently reported specific clinical features, including a higher severity of apathy and motor retardation. These features merit further investigation since they may help the differential diagnosis between MBI and PPDs.
摘要：
开发了轻度行为损害（MBI）概念，以确定迟发性持续性神经精神症状（NPS）是否可能是认知能力下降的早期表现。我们的研究旨在调查MBI在主要神经认知障碍（MND）和原发性精神疾病（PPD）方面的患病率和区别特征。总共招募了144名老年患者，他们被转诊到我们的精神科门诊服务。通过临床总体印象严重程度量表评估精神疾病的严重程度，精神病理学的严重程度通过简短精神病学评定量表（BPRS）进行评估，并通过全球功能评估量表对整体功能进行了评估。样本包括73名(50.6%)患有PPD的患者，40例（27.8%）MBI患者，31例（21.5%）MND患者。MND患者报告的精神疾病最严重，最高的BPRS总数，精神病,激活,和阴性症状评分，最低的功能。MBI和PPD患者的精神疾病严重程度和整体功能水平相当，但是MBI患者报告的BPRS总症状和阴性症状评分高于PPD患者。MBI患者经常报告特定的临床特征，包括更严重的冷漠和运动迟缓。这些特征值得进一步研究，因为它们可能有助于MBI和PPD之间的鉴别诊断。
