PDF(Pubmed)
Abstract：
Since the advent of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, an increased incidence of several endocrinological anomalies in acute-phase and/or long-term complications has been described. The aim of this review is to provide a broad overview of the available literature regarding changes in the worldwide epidemiology of endocrinological involvement in children since December 2019 and to report the evidence supporting its association with coronavirus disease 2019 (COVID-19). Although little is known regarding the involvement of endocrine organs during COVID-19 in children, the current evidence in adults and epidemiological studies on the pediatric population suggest the presence of a causal association between the virus and endocrinopathies. Untreated transient thyroid dysfunction, sick euthyroid syndrome, nonthyroidal illness syndrome, and hypothalamic-pituitary-adrenal (HPA) axis and central precocious puberty have been observed in children in acute infection and/or during multisystem inflammatory syndrome development. Furthermore, a higher frequency of ketoacidosis at onset in children with a new diagnosis of type 1 diabetes is reported in the literature. Although the direct association between COVID-19 and endocrinological involvement has not been confirmed yet, data on the development of different endocrinopathies in children, both during acute infection and as a result of its long-term complications, have been reported. This information is of primary importance to guide the management of patients with previous or current COVID-19.
摘要：
自从严重急性呼吸道综合症冠状病毒2（SARS-CoV-2）大流行以来，已经描述了急性期和/或长期并发症中几种内分泌异常的发生率增加。本综述的目的是对自2019年12月以来全球儿童内分泌流行病学变化的现有文献进行广泛概述，并报告支持其与2019年冠状病毒病（COVID-19）相关的证据。尽管对儿童COVID-19期间内分泌器官的参与知之甚少，目前在成人中的证据和对儿科人群的流行病学研究表明,该病毒与内分泌疾病之间存在因果关系.未经治疗的一过性甲状腺功能障碍，病态甲状腺功能正常综合征,非甲状腺疾病综合征，在急性感染和/或多系统炎症综合征发展过程中观察到下丘脑-垂体-肾上腺（HPA）轴和中枢性早熟。此外，有文献报道，在1型糖尿病新诊断的儿童中，酮症酸中毒的发生率更高。尽管COVID-19与内分泌参与之间的直接关联尚未得到证实，关于儿童不同内分泌疾病发展的数据，无论是在急性感染期间还是由于其长期并发症，已被报道。这些信息对于指导先前或当前患有COVID-19的患者的管理至关重要。
