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Abstract：
The present study aimed to assess the diagnostic test accuracy of different ultrasound scanning technologies in the detection of prostate cancer. A systematic search was conducted using the Cochrane Guidelines for Screening and Diagnostic Tests. We performed a systematic search in the international databases PubMed, Medline, Ovid, Embase and Cochrane Library. Searches were designed to find all studies that evaluated Micro-US, mpUS, SWE and CEUS as the main detection modalities for prostate cancer. This study was registered with Research Registry of systematic review and meta-analysis. The QUADAS-2 tool was utilized to perform quality assessment and bias analysis. The literature search generated 1376 studies. Of these, 320 studies were screened for eligibility, with 1056 studies being excluded. Overall, 26 studies with a total of 6370 patients met the inclusion criteria. The pooled sensitivity for grayscale, CEUS, SWE, Micro-US and mpUS modalities were 0.66 (95% CI 0.54-0.73) 0.73 (95% CI 0.58-0.88), 0.82 (95% CI 0.75-0.90), 0.85 (95% CI 0.76-0.94) and 0.87 (95% CI 0.71-1.03), respectively. Moreover, the pooled specificity for grayscale, CEUS, SWE, Micro-US and mpUS modalities were 0.56 (95% CI 0.21-0.90), 0.78 (95% CI 0.67-0.88), 0.76 (95% CI 0.65-0.88), 0.43 (95% CI 0.28-0.59) and 0.68 (95% CI 0.54-0.81), respectively. In terms of sensitivity, substantial heterogeneity between studies was detected (I2 = 72%, p = 0.000 < 0.05). In relation to specificity, extreme heterogeneity was detected (I2 = 93%, p = 0.000 < 0.05). Some studies proved that advanced ultrasound modalities such as mpUS, Micro-US, shear-wave elastography, contrast enhanced and micro-ultrasound are promising methods for the detection of prostate cancer.
摘要：
本研究旨在评估不同超声扫描技术在前列腺癌检测中的诊断测试准确性。使用Cochrane筛查和诊断测试指南进行了系统搜索。我们在PubMed国际数据库中进行了系统的搜索，Medline,奥维德,Embase和Cochrane图书馆。搜索旨在找到所有评估Micro-US的研究，MPUS,SWE和CEUS作为前列腺癌的主要检测方式。本研究在系统评价和荟萃分析的研究注册中心注册。使用QUADAS-2工具进行质量评估和偏倚分析。文献检索产生了1376项研究。其中,320项研究进行了资格筛选，1056项研究被排除在外。总的来说,26项研究共6370名患者符合纳入标准。灰度的合并灵敏度，CEUS,SWE,微美国和MPUS模式为0.66(95%CI0.54-0.73)0.73(95%CI0.58-0.88)，0.82（95%CI0.75-0.90），0.85（95%CI0.76-0.94）和0.87（95%CI0.71-1.03），分别。此外，灰度的合并特异性，CEUS,SWE,Micro-US和MPUS模式为0.56（95%CI0.21-0.90），0.78（95%CI0.67-0.88），0.76（95%CI0.65-0.88），0.43（95%CI0.28-0.59）和0.68（95%CI0.54-0.81），分别。在敏感度方面,检测到研究之间的实质性异质性(I2=72%，p=0.000<0.05)。关于特异性，检测到极端异质性(I2=93%，p=0.000<0.05)。一些研究证明，先进的超声模式，如MPUS，Micro-US,剪切波弹性成像，对比增强和微超声是检测前列腺癌的有前途的方法。
