PDF(Pubmed)
Abstract：
Premalignant lesions of the gastrointestinal tract are a group of disorders which act as the harbinger of malignant tumors. They are the ground-zero of neoplastic transformation, and their identification and management offer patients the best opportunity of blocking the progress of cancer. However, diagnoses of some of these conditions are hard to make, and their clinical importance is difficult to assess. Recent reports indicated that several claudin proteins have altered expressions in many cancers, including esophageal, gastric, colon, liver, and pancreatic cancers. The early identification of the aberrant expression of these proteins could lead to the early diagnosis and management of gastrointestinal tumors. Specifically, claudins -1, -2, -3, -4, and -18 are frequently overexpressed in gastrointestinal preneoplastic lesions. These altered expressions have shown clinical value in several tumors, providing diagnostic and prognostic information. In this article, we review the literature on the aberrant expression of claudins in preneoplastic lesions of the gastrointestinal tract. Additionally, we summarize their diagnostic and prognostic implications.
摘要：
胃肠道的癌前病变是一组作为恶性肿瘤先兆的疾病。它们是肿瘤转化的起点，他们的识别和管理为患者提供了阻止癌症进展的最佳机会。然而,对其中一些情况的诊断很难做出，其临床重要性难以评估。最近的报道表明，几种claudin蛋白在许多癌症中的表达发生了改变，包括食道,胃,结肠,肝脏,和胰腺癌。这些蛋白质的异常表达的早期鉴定可以导致胃肠道肿瘤的早期诊断和治疗。具体来说,claudins-1，-2，-3，-4和-18在胃肠道肿瘤前病变中经常过表达。这些改变的表达在几种肿瘤中显示出临床价值，提供诊断和预后信息。在这篇文章中,我们回顾了claudins在胃肠道癌前病变中的异常表达的文献。此外,我们总结了它们的诊断和预后意义.
