PDF(Pubmed)
Abstract：
The cancer profile of veterinarians has received little research attention, despite the profession potentially being exposed to a wide range of known and suspected carcinogens. In this large-scale cohort study, we assessed cancer incidence in veterinarians in Denmark, Finland, Iceland, Norway, and Sweden, across more than 40 years (1961-2005). The cohort comprised 4708 veterinarians and 119,503 person-years at follow-up. The overall cancer incidence in veterinarians was close to the incidence in the total population in all countries and in all age groups. In male veterinarians, the standardized incidence ratios (SIR) in 1961-1990 were elevated for colon cancer (1.86, 95% confidence interval (CI) 1.39-2.44), prostate cancer (1.35, 95% CI 1.07-1.67), and especially skin melanoma (3.62, 95% CI 2.78-2.84), while there was no longer any statistically significant excess in the more recent follow-up period. Decreased SIRs were observed for lip cancer (0.11, 95% CI 0.00-0.62), laryngeal cancer (0.38, 95% CI 0.12-0.89), lung cancer (0.59, 95% CI 0.47-0.74), and stomach cancer (0.58, 95% CI 0.38-0.86), without a marked change in SIR over time. Non-significant excesses among male veterinarians were also observed in Hodgkin lymphoma (1961-1990 only), and leukaemia. This multi-country study indicates that there was an elevated incidence of several cancer types among male veterinarians before the 1990s but not after that. Some of the findings might rather be attributed to lifestyle factors and not directly to work conditions, but the excess risk of cancers of kidney and bladder, for example, might be related to work exposures.
摘要：
兽医的癌症概况很少受到研究关注，尽管该行业可能会接触各种已知和可疑的致癌物。在这项大规模的队列研究中，我们评估了丹麦兽医的癌症发病率，芬兰,冰岛,挪威,瑞典,超过40年（1961-2005年）。该队列包括4708名兽医和119,503人年随访。兽医的总体癌症发病率接近所有国家和所有年龄组的总人口发病率。在男兽医中，1961-1990年结肠癌的标准化发病率（SIR）升高（1.86，95％置信区间（CI）1.39-2.44），前列腺癌（1.35，95%CI1.07-1.67），尤其是皮肤黑色素瘤（3.62，95%CI2.78-2.84），而在最近的随访期间不再有任何统计学上显著的超额。唇癌观察到SIR降低（0.11，95％CI0.00-0.62），喉癌（0.38，95%CI0.12-0.89），肺癌（0.59，95%CI0.47-0.74），和胃癌（0.58，95%CI0.38-0.86），随着时间的推移，SIR没有明显的变化。在霍奇金淋巴瘤（仅1961-1990年）中也观察到男性兽医中的非显着过度。和白血病.这项多国研究表明，在1990年代之前，男性兽医中几种癌症的发病率升高，但此后没有。一些发现可能归因于生活方式因素，而不是直接归因于工作条件，但是患肾癌和膀胱癌的风险过高，例如,可能与工作暴露有关。
