Abstract：
Riboflavin/UV-A corneal cross-linking (CXL) has been applied to treat corneal ulcers in adult horses, but its use in critically ill neonatal foals has not been described. Five cases of hospitalized, critically ill neonatal foals that were in intensive care with corneal ulcers, the ophthalmic treatment, and their outcome up to 1 year are described. A single treatment of CXL phototherapy was performed in three of five foals (five eyes). The application of a riboflavin ophthalmic solution for 20 minutes was followed by the UV-A light irradiation at 30 mW/cm2 for 3 minutes. Topical antibiotic administration was withdrawn after CXL. Two other foals received standard treatment. Descriptions of ocular lesions, fluorescein staining, and photographic documentation were recorded. The visual outcome, corneal transparency, and aesthetics, as well as healing time were evaluated in the follow-up. The frequency of topical medication considerably decreased in cases treated with CXL. Corneal opacity and pain decreased within 3 days following CXL. In the foals treated with CXL, the ulcers healed (fluorescein stain negative) in 24, 28, and 35 days after the onset of clinical signs and 10, 15, and 21, after CXL. No fibrosis or corneal scars were found in the cases treated with CXL. The two standard treatment cases healed after 26 and 36 days respectively. Corneal cross-linking may be an additional or alternative treatment of corneal ulcers in critically ill neonatal foals and may reduce the use of antibiotics.
摘要：
核黄素/UV-A角膜交联（CXL）已用于治疗成年马的角膜溃疡，但其在危重新生儿马驹中的应用尚未被描述。5例住院,患有角膜溃疡的重症监护新生儿小马驹，描述了眼科治疗及其长达一年的结果。在3/5马驹(5只眼)中进行CXL光疗的单一治疗。在施用核黄素眼用溶液20分钟之后,以30mW/cm2照射UV-A光3分钟。CXL后停止局部抗生素给药。另外两只小马驹接受了标准治疗。眼部病变的描述，记录荧光素染色和照相文件。视觉结果，角膜透明度和美学，在随访中评估愈合时间。在使用CXL治疗的病例中，局部用药的频率大大降低。CXL后3天内角膜混浊和疼痛减轻。在用CXL处理的小马驹中，在临床体征发作后24、28、35天和CXL后10、15、21天，溃疡愈合（荧光素染色阴性）。在用CXL治疗的病例中未发现纤维化或角膜疤痕。两个标准治疗病例分别在26天和36天后愈合。角膜交联可能是危重新生儿马驹角膜溃疡的额外或替代治疗，并可能减少抗生素的使用。
