关键词: DNase Extracellular DNA Fibrosis Leukotoxic hypercitrullination Macrophage Mitochondrial DNA Neutrophil extracellular traps (NETs)

来  源:   DOI:10.1016/j.intimp.2023.110834

Abstract:
Neutrophils are a major subset of leukocytes in human circulating blood. In some circumstances, neutrophils release neutrophil extracellular traps (NETs). lnitially, NETs were considered to have a strong antibacterial capacity. However, currently, NETs have been shown to have a pivotal impact on various diseases. Different stimulators induce the production of different types of NETs, and their biological functions and modes of clearance do not appear to be the same. In this review, we will discuss several important issues related to NETs in order to better understand the relationship between NETs and diseases, as well as how to utilize the characteristics of NETs for disease treatment.
摘要:
中性粒细胞是人循环血液中白细胞的主要子集。在某些情况下,中性粒细胞释放中性粒细胞胞外陷阱(NET)。最初,NET被认为具有很强的抗菌能力。然而,目前,NET已被证明对各种疾病具有关键影响。不同的刺激器诱导产生不同类型的NET,它们的生物学功能和清除方式似乎不一样。在这次审查中,我们将讨论几个与NETs相关的重要问题,以便更好地理解NETs与疾病之间的关系,以及如何利用NETs的特点进行疾病治疗。
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