PDF(Pubmed)
Abstract：
Residual kidney function for patients with chronic kidney disease (CKD) is associated with better quality of life and outcome; thus, strategies should be implemented to preserve kidney function. Among the multiple causes that promote kidney damage, gut dysbiosis due to increased uremic toxin production and endotoxemia need attention. Several strategies have been proposed to modulate the gut microbiota in these patients, and diet has gained increasing attention in recent years since it is the primary driver of gut dysbiosis. In addition, medications and faecal transplantation may be valid strategies. Modifying gut microbiota composition may mitigate chronic kidney damage and preserve residual kidney function. Although various studies have shown the influential role of diet in modulating gut microbiota composition, the effects of this modulation on residual kidney function remain limited. This review discusses the role of gut microbiota metabolism on residual kidney function and vice versa and how we could preserve the residual kidney function by modulating the gut microbiota balance.
摘要：
慢性肾脏病（CKD）患者的残余肾功能与更好的生活质量和预后相关；因此，应实施保护肾功能的策略。在促进肾脏损害的多种原因中，需要注意由于尿毒症毒素产生增加和内毒素血症引起的肠道生态失调。已经提出了几种策略来调节这些患者的肠道微生物群，近年来，饮食越来越受到关注，因为它是肠道菌群失调的主要驱动因素。此外,药物和粪便移植可能是有效的策略。改变肠道微生物群组成可以减轻慢性肾损伤并保留残余肾功能。尽管各种研究表明饮食在调节肠道微生物群组成中的重要作用，这种调节对残余肾功能的影响仍然有限。这篇综述讨论了肠道微生物群代谢对残余肾功能的作用，反之亦然，以及我们如何通过调节肠道微生物群平衡来保持残余肾功能。
