PDF(Pubmed)
Abstract：
The diagnosis of syphilis can be challenging for dermatologists and dermatopathologists. In particular, secondary syphilis can have different clinical and histopathological presentations. A granulomatous tissue response is an unusual finding in secondary syphilis. We report the case of a 77-year-old man who presented with a 4-week history of non-pruritic generalised macules, papules, nodules and plaques. Histopathologically, there was a dense perivascular and periadnexal lympho-histiocytic dermal infiltrate with non-palisading and non-caseifying epithelioid granulomas and abundant plasma cells. The diagnosis of syphilis was confirmed by serology and immunohistochemical detection of Treponema pallidum in the biopsy specimen. A brief overview of the diagnostic role of immunohistochemistry is also provided, with particular emphasis on reported cases of granulomatous secondary syphilis.
摘要：
梅毒的诊断对于皮肤科医生和皮肤病理学家来说可能是具有挑战性的。特别是,二期梅毒可以有不同的临床和组织病理学表现。肉芽肿组织反应是继发性梅毒的不寻常发现。我们报告了一名77岁的男子，他有4周的非瘙痒性全身性黄斑病史，丘疹,结节和斑块。组织病理学,有密集的血管周围和附件周围淋巴组织细胞性真皮浸润，伴有非淤积和非干酪性上皮样肉芽肿和丰富的浆细胞。通过活检标本中梅毒螺旋体的血清学和免疫组织化学检测证实了梅毒的诊断。还提供了免疫组织化学的诊断作用的简要概述，特别强调肉芽肿性二期梅毒的报告病例。
