PDF(Pubmed)
Abstract：
Candida auris is an opportunistic human pathogen that has rapidly spread to multiple countries and continents and has been associated with a high number of nosocomial outbreaks. Herein, we report the first case of C. auris in Portugal, which was associated with a patient transferred from Angola to an ICU in Portugal for liver transplantation after a SARS-CoV-2 infection. C. auris was isolated during the course of bronchoalveolar lavage, and it was subjected to antifungal susceptibility testing and whole-genome sequence analysis. This isolate presents low susceptibility to azoles and belongs to the genetic clade III with a phylogenetic placement close to African isolates. Although clade III has already been reported in Europe, taking into account the patient\'s clinical history, we cannot discard the possibility that the patient\'s colonization/infection occurred in Angola, prior to admission in the Portuguese hospital. Considering that C. auris is a fungal pathogen referenced by WHO as a critical priority, this case reinforces the need for continuous surveillance in a hospital setting.
摘要：
耳念珠菌是一种机会性人类病原体，已迅速传播到多个国家和大陆，并与大量的医院暴发有关。在这里，我们报道了葡萄牙首例C.auris,这与SARS-CoV-2感染后从安哥拉转移到葡萄牙ICU进行肝移植的患者有关。在支气管肺泡灌洗过程中分离出耳梭菌，并进行抗真菌药敏试验和全基因组序列分析。该分离株对唑类的敏感性较低，属于遗传进化枝III，其系统发育位置接近非洲分离株。尽管已经在欧洲报道了进化枝III，考虑到患者的临床病史，我们不能放弃患者定植/感染发生在安哥拉的可能性，在葡萄牙医院入院之前。考虑到金黄色葡萄球菌是一种被世卫组织列为关键优先事项的真菌病原体，这种情况加强了在医院环境中进行持续监测的必要性。
