Abstract：
In recent years, the incidence of liver disease has increased, becoming a major cause of death. Various liver diseases are intricately linked to pyroptosis, which is one of the most common forms of programmed cell death. As a powerful weapon in the fight against liver diseases, traditional Chinese medicine (TCM) can affect pyroptosis via a number of routes, including the classical, nucleotide oligomerization domain-like receptors protein 3/caspase-1/gasdermin D (GSDMD) pathway, the nonclassical lipopolysaccharide/caspase-11/GSDMD pathway, the ROS/caspase-3/gasdermin E pathway, the caspase-9/caspase-3/GSDMD pathway, and the Apaf-1/caspase-11/caspase-3 pathway. In this review, we provide an overview of pyroptosis, the interplay between pyroptosis and liver diseases, and the mechanisms through which TCM regulates pyroptosis in liver diseases. The information used in the text was collected and compiled from the databases of PubMed, Web of Science, Scopus, CNKI, and Wanfang Data up to June 2023. The search was not limited with regard to the language and country of the articles. Research and review articles were included, and papers with duplicate results or unrelated content were excluded. We examined the current understanding of the relationship between pyroptosis and liver diseases as well as the advances in TCM interventions to provide a resource for the identification of potential targets for TCM in the treatment of liver diseases.
摘要：
近年来,肝病的发病率增加了，成为死亡的主要原因。各种肝脏疾病与焦亡有着错综复杂的联系，这是程序性细胞死亡的最常见形式之一。作为对抗肝脏疾病的有力武器,中药（TCM）可以通过多种途径影响焦亡，包括古典，核苷酸寡聚化结构域样受体蛋白3/caspase-1/gasderminD（GSDMD）途径，非经典脂多糖/caspase-11/GSDMD途径，ROS/caspase-3/gasderminE途径，caspase-9/caspase-3/GSDMD通路，和Apaf-1/caspase-11/caspase-3途径。在这次审查中,我们提供了焦亡的概述，焦亡和肝脏疾病之间的相互作用，以及中医在肝脏疾病中调节焦亡的机制。文本中使用的信息是从PubMed的数据库中收集和编译的，WebofScience,Scopus,CNKI,和万方数据截至2023年6月。搜索不限于文章的语言和国家/地区。包括研究和评论文章，结果重复或内容无关的论文被排除。我们研究了当前对焦亡与肝脏疾病之间关系的理解以及中医干预措施的进展，为确定中医治疗肝脏疾病的潜在靶点提供了资源。
