关键词: RNA nanotechnology endosomal escape endosomes nanoparticles physicochemical properties ribose nucleic acid

来  源:   DOI:10.2144/fsoa-2023-0067   PDF(Pubmed)

Abstract:
Nanotechnology is the use of materials that have unique nanoscale properties. In recent years, nanotechnologies have shown promising results for human health, especially in cancer treatment. The self-assembly characteristic of RNA is a powerful bottom-up approach to the design and creation of nanostructures through interdisciplinary biological, chemical and physical techniques. The use of RNA nanotechnology in therapeutics is about to be realized. This review discusses different kinds of nano-based drug delivery systems and their characteristic features.
A branch of nanotechnology called RNA nanotechnology involves designing, studying, and utilizing synthetic structures based on RNA. This review discusses different kinds of nano-based drug delivery systems and their characteristic features. It aims to provide an overview of nanoparticles as a delivery system for gene therapy to treat diseases such as cancer. In order to enhance nanoparticle efficacy, these systems should be designed with this in mind in order to develop and test delivery systems rationally and scientifically.
摘要:
纳米技术是使用具有独特纳米级性质的材料。近年来,纳米技术对人类健康显示出了有希望的结果,特别是在癌症治疗中。RNA的自组装特性是一种强大的自下而上的方法,通过跨学科的生物学来设计和创建纳米结构,化学和物理技术。RNA纳米技术在治疗中的应用即将实现。本文综述了不同类型的纳米给药系统及其特点。
纳米技术的一个分支称为RNA纳米技术涉及设计,研究,利用基于RNA的合成结构。本文综述了不同类型的纳米给药系统及其特点。其目的是提供纳米颗粒作为基因治疗以治疗癌症等疾病的递送系统的概述。为了增强纳米粒子的功效,这些系统的设计应该考虑到这一点,以便合理和科学地开发和测试交付系统。
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