PDF(Pubmed)
Abstract：
UNASSIGNED: Schistosomiasis is causing high morbidity and significant mortality in endemic areas. Kato-Katz stool examination and urine filtration techniques are the conventional methods for the detection of intestinal and urinary schistosomiasis. The most appropriate diagnostic tools for the detection of schistosomiasis especially in low-prevalence settings should be used. Therefore, this study is aimed at investigating the diagnostic accuracy of S. mansoni and S. haematobium diagnostic tools in sub-Saharan Africa.
UNASSIGNED: Electronic databases such as PubMed, PubMed Central/Medline, HINARI, Scopus, EMBASE, Science Direct, Google Scholar, and Cochrane Library were reviewed. The pooled estimates and heterogeneity were determined using Midas in Stata 14.0. The diagnostic accuracy of index tests was compared using the hierarchical summary of the receiver operating characteristic (HSROC) curve in Stata 14.0.
UNASSIGNED: Twenty-four studies consisting of 12,370 individuals were tested to evaluate the accuracy of antigen, antibody, and molecular test methods for the detection of S. mansoni and S. haematobium. The pooled estimate of sensitivity and specificity of CCA was 88% (95% CI: 83-92) and 72 (95% CI: 62-80), respectively, when it is compared with parasitological stool examination for S. mansoni detection. On the other hand, ELISA showed a pooled estimate of sensitivity and specificity of 95% (95% CI: 93-96) and 35% (95% CI: 21-52), respectively, for the examination of S. mansoni using stool examination as a reference test. With regard to S. haematobium, the pooled estimate of sensitivity and specificity of polymerase chain reaction was 97% (95% CI: 78-100) and 94% (95% CI: 74-99), respectively. Moreover, the sensitivity and specificity of urine CCA vary between 41-80% and 55-91%, respectively, compared to urine microscopy.
UNASSIGNED: The effort of schistosomiasis elimination requires accurate case identification especially in low-intensity infections. This study showed that CCA had the highest sensitivity and moderate specificity for the diagnosis of S. mansoni. Similarly, the sensitivity of ELISA was excellent, but its specificity was low. The diagnostic accuracy of PCR for the detection of S. haematobium was excellent compared to urine microscopic examination.
UNASSIGNED: Electronic databases such as PubMed, PubMed Central/Medline, HINARI, Scopus, EMBASE, Science Direct, Google Scholar, and Cochrane Library were reviewed. The pooled estimates and heterogeneity were determined using Midas in Stata 14.0. The diagnostic accuracy of index tests was compared using the hierarchical summary of the receiver operating characteristic (HSROC) curve in Stata 14.0.
UNASSIGNED: Twenty-four studies consisting of 12,370 individuals were tested to evaluate the accuracy of antigen, antibody, and molecular test methods for the detection of S. mansoni and S. haematobium. The pooled estimate of sensitivity and specificity of CCA was 88% (95% CI: 83-92) and 72 (95% CI: 62-80), respectively, when it is compared with parasitological stool examination for S. mansoni detection. On the other hand, ELISA showed a pooled estimate of sensitivity and specificity of 95% (95% CI: 93-96) and 35% (95% CI: 21-52), respectively, for the examination of S. mansoni using stool examination as a reference test. With regard to S. haematobium, the pooled estimate of sensitivity and specificity of polymerase chain reaction was 97% (95% CI: 78-100) and 94% (95% CI: 74-99), respectively. Moreover, the sensitivity and specificity of urine CCA vary between 41-80% and 55-91%, respectively, compared to urine microscopy.
UNASSIGNED: The effort of schistosomiasis elimination requires accurate case identification especially in low-intensity infections. This study showed that CCA had the highest sensitivity and moderate specificity for the diagnosis of S. mansoni. Similarly, the sensitivity of ELISA was excellent, but its specificity was low. The diagnostic accuracy of PCR for the detection of S. haematobium was excellent compared to urine microscopic examination.
摘要：
■血吸虫病在流行地区引起高发病率和高死亡率。Kato-Katz粪便检查和尿液过滤技术是检测肠和尿血吸虫病的常规方法。应使用最合适的诊断工具来检测血吸虫病，尤其是在低患病率环境中。因此,本研究旨在调查撒哈拉以南非洲地区曼氏球菌和嗜血杆菌诊断工具的诊断准确性.
■电子数据库，如PubMed，PubMedCentral/Medline,Hinari,Scopus,EMBASE,科学直接，谷歌学者，和Cochrane图书馆进行了审查。合并的估计值和异质性是使用Stata14.0中的Midas确定的。使用Stata14.0中接收器工作特征（HSROC）曲线的分层摘要比较了指数测试的诊断准确性。
■对由12,370名个体组成的24项研究进行了测试，以评估抗原的准确性。抗体，以及检测曼氏芽孢杆菌和血吸虫的分子检验方法。CCA的敏感性和特异性的汇总估计为88％（95％CI：83-92）和72（95％CI：62-80），分别,当将其与寄生虫学粪便检查进行比较以检测曼氏芽孢杆菌。另一方面,ELISA显示，敏感性和特异性的汇总估计为95％（95％CI：93-96）和35％（95％CI：21-52），分别,用于检查S.mansoni使用粪便检查作为参考测试。关于嗜血链球菌，聚合酶链反应的敏感性和特异性的汇总估计为97％（95％CI：78-100）和94％（95％CI：74-99），分别。此外，尿液CCA的敏感性和特异性在41-80％和55-91％之间变化，分别,与尿液显微镜相比。
■消除血吸虫病的努力需要准确的病例识别，尤其是在低强度感染中。这项研究表明，CCA对曼氏球菌的诊断具有最高的敏感性和中等的特异性。同样，ELISA的灵敏度很高，但其特异性较低。与尿液显微镜检查相比，PCR检测血杆菌的诊断准确性极佳。
■电子数据库，如PubMed，PubMedCentral/Medline,Hinari,Scopus,EMBASE,科学直接，谷歌学者，和Cochrane图书馆进行了审查。合并的估计值和异质性是使用Stata14.0中的Midas确定的。使用Stata14.0中接收器工作特征（HSROC）曲线的分层摘要比较了指数测试的诊断准确性。
■对由12,370名个体组成的24项研究进行了测试，以评估抗原的准确性。抗体，以及检测曼氏芽孢杆菌和血吸虫的分子检验方法。CCA的敏感性和特异性的汇总估计为88％（95％CI：83-92）和72（95％CI：62-80），分别,当将其与寄生虫学粪便检查进行比较以检测曼氏芽孢杆菌。另一方面,ELISA显示，敏感性和特异性的汇总估计为95％（95％CI：93-96）和35％（95％CI：21-52），分别,用于检查S.mansoni使用粪便检查作为参考测试。关于嗜血链球菌，聚合酶链反应的敏感性和特异性的汇总估计为97％（95％CI：78-100）和94％（95％CI：74-99），分别。此外，尿液CCA的敏感性和特异性在41-80％和55-91％之间变化，分别,与尿液显微镜相比。
■消除血吸虫病的努力需要准确的病例识别，尤其是在低强度感染中。这项研究表明，CCA对曼氏球菌的诊断具有最高的敏感性和中等的特异性。同样，ELISA的灵敏度很高，但其特异性较低。与尿液显微镜检查相比，PCR检测血杆菌的诊断准确性极佳。
