Abstract：
OBJECTIVE: The aim of this study is to analyze functional outcomes of soft palate reconstruction after oncologic surgery.
METHODS: This study was conducted in conformity with the PRISMA statement. A single arm meta-analysis was performed for feeding tube dependence (FTD) (primary outcome), velopharyngeal insufficiency (VPI) and hypernasality (HN) (secondary outcomes) incidences.
RESULTS: A total of 510 patients (males: 77.75%, n = 353/454) with a median age of 58 years (n = 480/510; 95% CI 57.0-61.0) who underwent soft palate surgical resection with primary reconstruction were included. Overall, the cumulative FTD rate was 1.55% (n = 28/510; 95% CI 0.24-3.96%), the VPI rate was 22.18% (n = 119/379; 95% CI 12.99-33.02%), and the HN rate was 33.01% (n = 88/234; 95% CI 19.03-46.61%).
CONCLUSIONS: Soft palate reconstruction results in a low incidence of FTD, and most patients resume a full oral diet. Both obturators, primary closure, local and free flaps seem good reconstructive options. Nevertheless, more specific postoperative functional deficiencies like VPI and HN owns higher incidences, potentially affecting the quality of the swallowing and speaking function and the patient\'s quality of life.
METHODS: This study was conducted in conformity with the PRISMA statement. A single arm meta-analysis was performed for feeding tube dependence (FTD) (primary outcome), velopharyngeal insufficiency (VPI) and hypernasality (HN) (secondary outcomes) incidences.
RESULTS: A total of 510 patients (males: 77.75%, n = 353/454) with a median age of 58 years (n = 480/510; 95% CI 57.0-61.0) who underwent soft palate surgical resection with primary reconstruction were included. Overall, the cumulative FTD rate was 1.55% (n = 28/510; 95% CI 0.24-3.96%), the VPI rate was 22.18% (n = 119/379; 95% CI 12.99-33.02%), and the HN rate was 33.01% (n = 88/234; 95% CI 19.03-46.61%).
CONCLUSIONS: Soft palate reconstruction results in a low incidence of FTD, and most patients resume a full oral diet. Both obturators, primary closure, local and free flaps seem good reconstructive options. Nevertheless, more specific postoperative functional deficiencies like VPI and HN owns higher incidences, potentially affecting the quality of the swallowing and speaking function and the patient\'s quality of life.
摘要：
目的：本研究的目的是分析肿瘤手术后软腭重建的功能结果。
方法：本研究按照PRISMA声明进行。对饲管依赖性（FTD）（主要结局）进行了单臂荟萃分析，咽喉功能不全（VPI）和鼻塞过多（HN）（次要结局）的发生率。
结果：共510例患者（男性：77.75%，n=353/454），中位年龄为58岁（n=480/510；95％CI57.0-61.0），接受软腭手术切除并进行初次重建。总的来说,累积FTD率为1.55%(n=28/510；95%CI0.24-3.96%)，VPI率为22.18%（n=119/379；95%CI12.99-33.02%），HN率为33.01%(n=88/234;95%CI19.03-46.61%)。
结论：软腭重建术导致FTD发生率低，大多数患者恢复完全的口服饮食。两个闭塞器，初级闭合，局部和自由皮瓣似乎是很好的重建选择。然而，更具体的术后功能缺陷，如VPI和HN，发病率更高，可能影响吞咽和说话功能的质量和患者的生活质量。
方法：本研究按照PRISMA声明进行。对饲管依赖性（FTD）（主要结局）进行了单臂荟萃分析，咽喉功能不全（VPI）和鼻塞过多（HN）（次要结局）的发生率。
结果：共510例患者（男性：77.75%，n=353/454），中位年龄为58岁（n=480/510；95％CI57.0-61.0），接受软腭手术切除并进行初次重建。总的来说,累积FTD率为1.55%(n=28/510；95%CI0.24-3.96%)，VPI率为22.18%（n=119/379；95%CI12.99-33.02%），HN率为33.01%(n=88/234;95%CI19.03-46.61%)。
结论：软腭重建术导致FTD发生率低，大多数患者恢复完全的口服饮食。两个闭塞器，初级闭合，局部和自由皮瓣似乎是很好的重建选择。然而，更具体的术后功能缺陷，如VPI和HN，发病率更高，可能影响吞咽和说话功能的质量和患者的生活质量。
