The data of our study were collected from PubMed, Embase, Web of Science, Cochrane Library, China National Knowledge Infrastructure and WAN FANG databases from inception to November 2022. Using the Review Manager V.5.4 software, the meta-analysis was performed.
A total of 18 139 patients from 22 studies were included in our analysis. In the Asian subgroup, the patients with T2DM group had a significantly higher frequency of HCMV infection and older age compared with the healthy group. In the European, the frequency of HCMV infection in the T2DM was lower than the healthy group, although this difference was not statistically significant. After adjusting for demographic factors, the adjusted OR of T2DM for risk of by HCMV status was not found to be significant (adjusted OR=1.19, 95% CI=0.88 to 1.62, p>0.05). Additionally, T2DM with vasculopathy had a significantly higher rate of HCMV infection compared with those without vasculopathy (OR=1.87, 95% CI=1.24 to 2.83, p<0.05). Among T2DM with HCMV infection, there were significant increases in fasting blood glucose levels and the proportion of CD8+ T lymphocytes. Conversely, fasting blood insulin levels, the proportion of CD4+ T lymphocyte and the CD4+/CD8+ ratio were significantly decreased compared with the healthy group.
At present, the available evidence does not provide a clear understanding of whether there is a significant association between T2DM and HCMV infection. Additionally, T2DM with HCMV infection exhibited significantly worse blood glucose regulation and immune markers, as well as a higher frequency of vasculopathy.
CRD42022342066.
方法:我们的研究数据来自PubMed,Embase,WebofScience,科克伦图书馆,中国国家知识基础设施和万方网数据库从成立到2022年11月。使用ReviewManagerV.5.4软件,进行了荟萃分析.
结果:我们的分析包括22项研究中的18139例患者。在亚洲分组中,与健康组相比,T2DM组患者HCMV感染频率明显较高,且年龄较大.在欧洲,2型糖尿病患者HCMV感染频率低于健康组,尽管这种差异没有统计学意义。在调整了人口因素后,T2DM对HCMV状态的风险的校正OR没有发现显著(校正OR=1.19,95%CI=0.88~1.62,p>0.05).此外,有血管病变的T2DM患者HCMV感染率明显高于无血管病变的T2DM患者(OR=1.87,95%CI=1.24~2.83,p<0.05)。在伴有HCMV感染的T2DM中,空腹血糖水平和CD8+T淋巴细胞比例显著升高。相反,空腹血胰岛素水平,与健康组相比,CD4+T淋巴细胞比例和CD4+/CD8+比值显著降低。
结论:目前,现有证据并不能明确了解T2DM和HCMV感染之间是否存在显著关联.此外,2型糖尿病伴HCMV感染表现出明显更差的血糖调节和免疫标志物,以及更高的血管病变频率。
■CRD42022342066。