Abstract：
Epilepsy is often linked to various psychiatric symptoms, with anxiety, depression, and interictal dysphoric disorders being the most prevalent. Few studies have investigated posttraumatic stress disorder (PTSD) in epilepsy, but they suggest a notable prevalence of PTSD. PTSD is known to be associated with cognitive impairments, particularly memory and executive functions. Our proposed exploratory study aims to investigate executive attentional control and emotional inhibition in patients with drug-resistant epilepsy (DRE) who exhibit PTSD symptoms compared with a healthy control group. Additionally, some PWE can manage their seizures using emotional and cognitive strategies, we find it relevant to explore the connection between their regulation abilities, cognitive control performance, and PTSD symptoms. We included 54 PWE and 60 healthy participants. They completed anxiety and depression scales as well as two questionnaires assessing PTSD symptoms and a questionnaire that measured the perceived self-control of seizures. We measured executive control using an executive control task (Attention Network Test, ANT) and an emotional Go/No-Go task. We found a positive correlation between PTSD scores (PDS-5) and performance at the ANT task. In contrast, in the emotional inhibition (Go/No-Go) task, behavioral inhibition errors were positively correlated with PTSD scores, specifically with hypervigilance symptoms in PTSD+ patients. There was a positive correlation between response reaction times in an aversive condition and PTSD scores: the more severe the PTSD symptoms, the faster the PWE identified stimuli in the angry face condition of the Go/No-Go task. Regarding perceived seizure control, we found correlations between alertness and PTSD symptoms associated with seizure anticipation during the inter- and peri-ictal periods. Patients with PTSD symptoms reported better seizure control. Our findings suggest that epilepsy patients with PTSD experience cognitive changes such as heightened executive attentional control, weakened emotional inhibition, and improved seizure control perception.
摘要：
癫痫通常与各种精神症状有关，带着焦虑,抑郁症,发作间焦虑障碍是最普遍的。很少有研究调查癫痫的创伤后应激障碍（PTSD），但他们表明PTSD的患病率显著。已知PTSD与认知障碍有关，特别是记忆和执行功能。我们提出的探索性研究旨在调查与健康对照组相比，表现出PTSD症状的耐药性癫痫（DRE）患者的执行注意控制和情绪抑制。此外,一些PWE可以通过情绪和认知策略来控制癫痫发作，我们发现这与探索他们调节能力之间的联系有关，认知控制表现，和PTSD症状。我们包括54名PWE和60名健康参与者。他们完成了焦虑和抑郁量表以及两份评估PTSD症状的问卷和一份测量癫痫发作自我控制感的问卷。我们使用执行控制任务测量执行控制(注意网络测试，ANT)和一个情绪化的Go/No-Go任务。我们发现PTSD得分（PDS-5）与ANT任务的表现之间存在正相关。相比之下,在情绪抑制(Go/No-Go)任务中，行为抑制误差与PTSD评分呈正相关，特别是PTSD+患者的过度警觉症状。在厌恶状态下的反应反应时间和PTSD评分之间存在正相关：PTSD症状越严重，PWE在Go/No-Go任务的愤怒面部条件下识别刺激的速度越快。关于感知的癫痫发作控制，我们发现警觉性和PTSD症状与发作间期和围发作期癫痫发作预期相关.有PTSD症状的患者报告癫痫发作控制更好。我们的研究结果表明，患有PTSD的癫痫患者会经历认知变化，例如执行注意力控制增强，情绪抑制减弱，和改善癫痫控制感知。
