PDF(Pubmed)
Abstract：
DNA nanoparticles hold great promise for a range of biological applications, including the development of cutting-edge treatments and diagnostic tests. Their subnanometer-level addressability enables precise, specific modifications with a variety of chemical and biological entities, making them ideal as diagnostic instruments and carriers for targeted delivery. This paper focuses on the potential of DNA nanomaterials, which offer scalability, programmability, and functionality. For example, they can be engineered to provide highly specific biosensing and bioimaging capabilities and show promise as a platform for disease diagnosis and treatment. Successful operation of various biomedical nanomaterials has been demonstrated both in vitro and in vivo. However, there are still significant challenges to overcome, including the need to improve the scalability and reliability of the technology, and to ensure safety in clinical applications. We discuss these challenges and opportunities in detail and highlight the progress and prospects of DNA nanotechnology for biomedical applications.
摘要：
DNA纳米颗粒在一系列生物应用中有着巨大的前景，包括尖端治疗和诊断测试的开发。它们的亚纳米级可寻址性使精确，用各种化学和生物实体进行特定的修饰，使它们成为有针对性的交付的诊断工具和载体的理想选择。本文主要研究DNA纳米材料的潜力,它提供了可扩展性，可编程性，和功能。例如,它们可以被设计为提供高度特异性的生物传感和生物成像能力，并有望成为疾病诊断和治疗的平台。已经在体外和体内证明了各种生物医学纳米材料的成功操作。然而,仍然有重大挑战需要克服，包括需要提高技术的可扩展性和可靠性，并确保临床应用的安全性。我们详细讨论了这些挑战和机遇，并强调了DNA纳米技术在生物医学应用中的进展和前景。
