PDF(Pubmed)
Abstract：
With the restriction of organophosphorus and other insecticides, pyrethroids are currently the second most-used group of insecticides worldwide due to their advantages such as effectiveness and low toxicity for mammalian. Animal studies and clinical case reports have documented associations between adverse health outcomesand exposure to pyrethroids. At present, the association between chronic pyrethroid exposure and osteoarthritis (OA) remains elusive.
Cross-sectional data from the National Health and Nutrition Examination Survey 1999-2002 and 2007-2014 were used to explore the associations of pyrethroid exposure and OA. Urinary level of 3-phenoxybenzoic acid (3-PBA) in urine samples was used to evaluate the exposure of pyrethroid, and OA was determined on the basis of self-reported physician diagnoses. Multivariable logistic regression models were used to investigate the association between pyrethroid exposure and OA.
Among the 6528 participants, 650 had OA. The weighted geometric mean of urinary volume-based 3-PBA concentration were 0.45 µg/L. With adjustments for major confounders, compared to participants in the lowest quartile of urinary volume-based 3-PBA, those in the highest quartilehad higher odds of OA (odds ratio, 1.39; 95% confidence interval: 1.01, 1.92). There was no nonlinear relationship between urinary volume-based 3-PBA and OA (P for non-linearity = 0.89).
High urinary 3-PBA concentration was associated with increased OA odds in the US adults. Pyrethroid exposure in the population should be monitored regularly.
Cross-sectional data from the National Health and Nutrition Examination Survey 1999-2002 and 2007-2014 were used to explore the associations of pyrethroid exposure and OA. Urinary level of 3-phenoxybenzoic acid (3-PBA) in urine samples was used to evaluate the exposure of pyrethroid, and OA was determined on the basis of self-reported physician diagnoses. Multivariable logistic regression models were used to investigate the association between pyrethroid exposure and OA.
Among the 6528 participants, 650 had OA. The weighted geometric mean of urinary volume-based 3-PBA concentration were 0.45 µg/L. With adjustments for major confounders, compared to participants in the lowest quartile of urinary volume-based 3-PBA, those in the highest quartilehad higher odds of OA (odds ratio, 1.39; 95% confidence interval: 1.01, 1.92). There was no nonlinear relationship between urinary volume-based 3-PBA and OA (P for non-linearity = 0.89).
High urinary 3-PBA concentration was associated with increased OA odds in the US adults. Pyrethroid exposure in the population should be monitored regularly.
摘要：
背景：由于有机磷和其他杀虫剂的限制，拟除虫菊酯由于其对哺乳动物的有效性和低毒性等优点,目前是世界上第二大使用的杀虫剂。动物研究和临床病例报告已记录了不良健康结局与拟除虫菊酯暴露之间的关联。目前,慢性拟除虫菊酯暴露与骨关节炎(OA)之间的关联仍然难以捉摸.
方法：使用1999-2002年和2007-2014年全国健康和营养检查调查的横断面数据来探索拟除虫菊酯暴露与OA的相关性。尿液中3-苯氧基苯甲酸（3-PBA）的尿液水平用于评估拟除虫菊酯的暴露，OA是根据自我报告的医师诊断确定的.使用多变量逻辑回归模型来研究拟除虫菊酯暴露与OA之间的关系。
结果：在6528名参与者中，650得OA。基于尿量的3-PBA浓度的加权几何平均值为0.45µg/L。随着主要混杂因素的调整，与基于尿量的3-PBA最低四分位数的参与者相比，四分位数最高的人患OA的几率更高(赔率比，1.39；95%置信区间：1.01，1.92）。基于尿量的3-PBA和OA之间没有非线性关系（非线性P=0.89）。
结论：在美国成年人中，高尿3-PBA浓度与OA几率增加相关。应定期监测人群中拟除虫菊酯的暴露情况。
方法：使用1999-2002年和2007-2014年全国健康和营养检查调查的横断面数据来探索拟除虫菊酯暴露与OA的相关性。尿液中3-苯氧基苯甲酸（3-PBA）的尿液水平用于评估拟除虫菊酯的暴露，OA是根据自我报告的医师诊断确定的.使用多变量逻辑回归模型来研究拟除虫菊酯暴露与OA之间的关系。
结果：在6528名参与者中，650得OA。基于尿量的3-PBA浓度的加权几何平均值为0.45µg/L。随着主要混杂因素的调整，与基于尿量的3-PBA最低四分位数的参与者相比，四分位数最高的人患OA的几率更高(赔率比，1.39；95%置信区间：1.01，1.92）。基于尿量的3-PBA和OA之间没有非线性关系（非线性P=0.89）。
结论：在美国成年人中，高尿3-PBA浓度与OA几率增加相关。应定期监测人群中拟除虫菊酯的暴露情况。
