Abstract：
OBJECTIVE: This systematic review aimed to answer whether, in (P) individuals undergoing orthognathic surgery, (I) low-level laser therapy (LLLT) during or shortly after the surgical procedure compared to (C) pharmacologic therapy alone or no therapy for improvement of post-intervention complications relieves (O) postoperative inflammatory events in (S) randomized clinical trials.
METHODS: A preliminary electronic search was conducted for references with language following a Latin (Roman) alphabet in seven databases index, and gray literature without restriction on language or publication period. Risk of bias was performed by RoB 2.0 tool, and meta-analysis used mean differences (MD) for edema and mouth opening and standardized mean differences (SMD) for pain scores (p < 0.05, Revman®).
RESULTS: A total of 91 control patients and 114 LLLT patients were included. The wavelengths ranged from 660 to 940 nm, and the applied energy density was between 5 and 100 J/cm2 at mostly extraoral distributed points. LLLT significantly reduced edema (MD = - 4.27, CI95% - 5.13 to - 3.41 mm) in the period from 5 days to 2 weeks postoperatively (p < 0.001) and showed strongly reduced pain scores (SMD = - 1.37, I95% = - 1.99 to - 0.75) between 1 day and 5 weeks (p < 0.001), without significantly interfering with mouth opening (p = 0.110). Despite the low risk of bias, high heterogeneity among studies (I2 > 70%) and small sample sizes made the certainty of GRADE evidence low.
CONCLUSIONS: This SR demonstrated that LLLT effectively controls pain and edema after orthognathic surgery.
CONCLUSIONS: Systematic review that summarizes the use of photobiomodulation on orthognathic surgery.
METHODS: A preliminary electronic search was conducted for references with language following a Latin (Roman) alphabet in seven databases index, and gray literature without restriction on language or publication period. Risk of bias was performed by RoB 2.0 tool, and meta-analysis used mean differences (MD) for edema and mouth opening and standardized mean differences (SMD) for pain scores (p < 0.05, Revman®).
RESULTS: A total of 91 control patients and 114 LLLT patients were included. The wavelengths ranged from 660 to 940 nm, and the applied energy density was between 5 and 100 J/cm2 at mostly extraoral distributed points. LLLT significantly reduced edema (MD = - 4.27, CI95% - 5.13 to - 3.41 mm) in the period from 5 days to 2 weeks postoperatively (p < 0.001) and showed strongly reduced pain scores (SMD = - 1.37, I95% = - 1.99 to - 0.75) between 1 day and 5 weeks (p < 0.001), without significantly interfering with mouth opening (p = 0.110). Despite the low risk of bias, high heterogeneity among studies (I2 > 70%) and small sample sizes made the certainty of GRADE evidence low.
CONCLUSIONS: This SR demonstrated that LLLT effectively controls pain and edema after orthognathic surgery.
CONCLUSIONS: Systematic review that summarizes the use of photobiomodulation on orthognathic surgery.
摘要：
目的：本系统综述旨在回答，在（P）接受正颌手术的个体中，(I)与(C)单独的药物治疗或无治疗以改善干预后并发症相比,在(S)随机临床试验中,(I)在外科手术期间或之后不久的低水平激光治疗(LLLT)可缓解(O)术后炎症事件。
方法：在七个数据库索引中，对使用拉丁（罗马）字母的语言进行了初步电子搜索，和灰色文献，没有语言或出版期限的限制。偏倚风险由RoB2.0工具执行，和荟萃分析使用水肿和张口的平均差异（MD）和疼痛评分的标准化平均差异（SMD）（p<0.05，Revman®）。
结果：共纳入91例对照患者和114例LLLT患者。波长范围从660到940nm，在大多数口外分布点，施加的能量密度在5至100J/cm2之间。LLLT在术后5天至2周期间显着减轻水肿（MD=-4.27，CI95％-5.13至-3.41mm）（p<0.001），并且在1天至5周（p<0.001）之间显示出疼痛评分大大降低（SMD=-1.37，I95％=-1.99至-0.75），没有明显干扰张口（p=0.110）。尽管偏见的风险很低，研究间的高度异质性(I2>70%)和小样本量使得GRADE证据的确定性较低。
结论：该SR证明LLLT可有效控制正颌手术后的疼痛和水肿。
结论：系统综述，总结光生物调节在正颌手术中的应用。
方法：在七个数据库索引中，对使用拉丁（罗马）字母的语言进行了初步电子搜索，和灰色文献，没有语言或出版期限的限制。偏倚风险由RoB2.0工具执行，和荟萃分析使用水肿和张口的平均差异（MD）和疼痛评分的标准化平均差异（SMD）（p<0.05，Revman®）。
结果：共纳入91例对照患者和114例LLLT患者。波长范围从660到940nm，在大多数口外分布点，施加的能量密度在5至100J/cm2之间。LLLT在术后5天至2周期间显着减轻水肿（MD=-4.27，CI95％-5.13至-3.41mm）（p<0.001），并且在1天至5周（p<0.001）之间显示出疼痛评分大大降低（SMD=-1.37，I95％=-1.99至-0.75），没有明显干扰张口（p=0.110）。尽管偏见的风险很低，研究间的高度异质性(I2>70%)和小样本量使得GRADE证据的确定性较低。
结论：该SR证明LLLT可有效控制正颌手术后的疼痛和水肿。
结论：系统综述，总结光生物调节在正颌手术中的应用。
