PDF(Pubmed)
Abstract：
Heparin is a negatively charged polysaccharide with various chain lengths and a hydrophilic backbone. Due to its fascinating chemical and physical properties, nontoxicity, biocompatibility, and biodegradability, heparin has been extensively used in different fields of medicine, such as cardiovascular and hematology. This review highlights recent and future advancements in designing materials based on heparin for various biomedical applications. The physicochemical and mechanical properties, biocompatibility, toxicity, and biodegradability of heparin are discussed. In addition, the applications of heparin-based materials in various biomedical fields, such as drug/gene delivery, tissue engineering, cancer therapy, and biosensors, are reviewed. Finally, challenges, opportunities, and future perspectives in preparing heparin-based materials are summarized.
摘要：
肝素是带负电荷的多糖,具有各种链长和亲水主链。由于其迷人的化学和物理性质，无毒，生物相容性，和生物降解性，肝素已广泛应用于不同的医学领域,如心血管和血液学。这篇综述重点介绍了用于各种生物医学应用的基于肝素的材料设计的最新和未来进展。物理化学和机械性能，生物相容性，毒性,讨论了肝素的生物降解性。此外,肝素基材料在各种生物医学领域的应用，如药物/基因递送，组织工程,癌症治疗,和生物传感器，被审查。最后,挑战,机遇,并总结了制备肝素基材料的未来前景。
