Abstract：
BACKGROUND: Mefloquine is an antimalarial medicine used to prevent and treat malaria. This medicine has some side effects, including ototoxicity. This study, which was designed in two phases, aimed to investigate the side effects of mefloquine and evaluate the preventive effects of electrical stimulation on these side effects.
METHODS: In the first phase, two doses of mefloquine (50 and 200 μM ) were injected into male rats, and after 7 days, they were evaluated by an auditory brainstem response (ABR) test. In the second phase, electrical stimulation was applied for 10 days, and then a toxic dose of mefloquine was injected. Similar to the first phase of the study, the animals were evaluated by an ABR test after 7 days.
RESULTS: In the first phase, the results showed that a high dose of mefloquine increased the ABR threshold and wave I latency; however, these changes were not observed in the second phase.
CONCLUSIONS: Application of electrical stimulation could prevent the ototoxic effects of mefloquine. According to the findings of the present study, electrical stimulation can be used as a preconditioner to prevent the ototoxic effects of mefloquine.
METHODS: In the first phase, two doses of mefloquine (50 and 200 μ
RESULTS: In the first phase, the results showed that a high dose of mefloquine increased the ABR threshold and wave I latency; however, these changes were not observed in the second phase.
CONCLUSIONS: Application of electrical stimulation could prevent the ototoxic effects of mefloquine. According to the findings of the present study, electrical stimulation can be used as a preconditioner to prevent the ototoxic effects of mefloquine.
摘要：
背景：甲氟喹是一种用于预防和治疗疟疾的抗疟药。这种药有一些副作用，包括耳毒性.这项研究,分两个阶段设计，目的探讨甲氟喹的副作用，并评价电刺激对这些副作用的预防作用。
方法：在第一阶段，向雄性大鼠注射两种剂量的甲氟喹（50和200μM ），7天后,他们通过听觉脑干反应(ABR)测试进行评估.在第二阶段,施加电刺激10天，然后注射有毒剂量的甲氟喹。类似于研究的第一阶段，7天后通过ABR试验评估动物。
结果：在第一阶段，结果表明，高剂量甲氟喹增加了ABR阈值和I波潜伏期；然而，在第二阶段未观察到这些变化.
结论：应用电刺激可以预防甲氟喹的耳毒性作用。根据本研究的结果，电刺激可以用作预处理器，以防止甲氟喹的耳毒性作用。
方法：在第一阶段，向雄性大鼠注射两种剂量的甲氟喹（50和200μ
结果：在第一阶段，结果表明，高剂量甲氟喹增加了ABR阈值和I波潜伏期；然而，在第二阶段未观察到这些变化.
结论：应用电刺激可以预防甲氟喹的耳毒性作用。根据本研究的结果，电刺激可以用作预处理器，以防止甲氟喹的耳毒性作用。
