PDF(Pubmed)
Abstract：
The skin is known to be the largest organ in the human body, while also being exposed to environmental elements. This indicates that skin is highly susceptible to physical infliction, as well as damage resulting from medical conditions such as obesity and diabetes. The wound management costs in hospitals and clinics are expected to rise globally over the coming years, which provides pressure for more wound healing aids readily available in the market. Recently, nanomaterials have been gaining traction for their potential applications in various fields, including wound healing. Here, we discuss various inorganic nanoparticles such as silver, titanium dioxide, copper oxide, cerium oxide, MXenes, PLGA, PEG, and silica nanoparticles with their respective roles in improving wound healing progression. In addition, organic nanomaterials for wound healing such as collagen, chitosan, curcumin, dendrimers, graphene and its derivative graphene oxide were also further discussed. Various forms of nanoparticle drug delivery systems like nanohydrogels, nanoliposomes, nanofilms, and nanoemulsions were discussed in their function to deliver therapeutic agents to wound sites in a controlled manner.
摘要：
众所周知，皮肤是人体最大的器官，同时也暴露于环境因素。这表明皮肤极易受到身体伤害，以及肥胖和糖尿病等医疗条件造成的损害。预计未来几年，医院和诊所的伤口管理成本将在全球范围内上升。这为市场上容易获得的更多伤口愈合助剂提供了压力。最近,纳米材料因其在各个领域的潜在应用而备受关注，包括伤口愈合。这里,我们讨论了各种无机纳米粒子，如银，二氧化钛,氧化铜,氧化铈,MXenes,PLGA,PEG，和二氧化硅纳米颗粒在改善伤口愈合进程中具有各自的作用。此外,用于伤口愈合的有机纳米材料，如胶原蛋白，壳聚糖,姜黄素,树枝状聚合物,还进一步讨论了石墨烯及其衍生物氧化石墨烯。各种形式的纳米颗粒药物递送系统，如纳米水凝胶，纳米脂质体，纳米薄膜，和纳米乳剂讨论了它们以受控方式将治疗剂递送至伤口部位的功能。
