PDF(Pubmed)
Abstract：
There are no previous studies of the psychopathology associated with different aetiologies of chronic pruritus. A systematic review was performed of cohort and case-control studies comparing healthy controls with patients with chronic pruritus related to primary dermatoses, systemic diseases, psychogenic pruritus, idiopathic pruritus, prurigo nodularis and/or lichen simplex chronicus. The review was registered in PROSPERO and performed according to the PRISMA statement, which allowed the inclusion of 26 studies. The quality of eligible studies was assessed using the modified Newcastle-Ottawa Scale. Most of the studies concern primary dermatoses and systemic diseases. Sleep disorders are a common comorbidity interrelated with pruritus, anxiety and depressive symptoms, in primary dermatoses. Sleep disorders are linked with pruritus and depressive symptoms in end-stage renal disease and hepatobiliary disease. Depressive and anxiety symptoms are associated with psychogenic pruritus. Psychogenic pruritus, lichen simplex chronicus and some primary dermatoses are linked with personality characteristics. Further studies are required to explore in depth the psychopathology linked with psychogenic pruritus and prurigo nodularis, as well as psychopathology linked with other primary dermatoses and systemic disorders associated with chronic pruritus, and to better differentiate psychogenic pruritus from psychopathological characteristics linked with other aetiologies of chronic pruritus, in order to improve the management of patients with chronic pruritus.
摘要：
以前没有与慢性瘙痒的不同病因相关的精神病理学研究。对队列和病例对照研究进行了系统评价，比较了健康对照与原发性皮肤病相关的慢性瘙痒患者。全身性疾病,心因性瘙痒,特发性瘙痒,结节性痒疹和/或单纯性慢性苔藓。审查已在PROSPERO注册，并根据PRISMA声明进行，允许纳入26项研究。使用改良的纽卡斯尔-渥太华量表评估合格研究的质量。大多数研究涉及原发性皮肤病和全身性疾病。睡眠障碍是与瘙痒相关的常见合并症，焦虑和抑郁症状,在原发性皮肤病中。睡眠障碍与终末期肾病和肝胆疾病的瘙痒和抑郁症状有关。抑郁和焦虑症状与心理性瘙痒有关。心因性瘙痒,慢性单纯性苔藓和一些原发性皮肤病与个性特征有关。需要进一步的研究来深入探讨与心因性瘙痒和结节性瘙痒相关的精神病理学，以及与其他原发性皮肤病和与慢性瘙痒相关的系统性疾病相关的精神病理学，为了更好地区分心理性瘙痒和与其他慢性瘙痒病因相关的精神病理学特征，以改善慢性瘙痒患者的管理。
