PDF(Pubmed)
Abstract：
mRNA surveillance pathways are essential for accurate gene expression and to maintain translation homeostasis, ensuring the production of fully functional proteins. Future insights into mRNA quality control pathways will enable us to understand how cellular mRNA levels are controlled, how defective or unwanted mRNAs can be eliminated, and how dysregulation of these can contribute to human disease. Here we review translation-coupled mRNA quality control mechanisms, including the non-stop and no-go mRNA decay pathways, describing their mechanisms, shared trans-acting factors, and differences. We also describe advances in our understanding of the nonsense-mediated mRNA decay (NMD) pathway, highlighting recent mechanistic findings, the discovery of novel factors, as well as the role of NMD in cellular physiology and its impact on human disease.
摘要：
mRNA监测途径对于准确的基因表达和维持翻译稳态至关重要，确保生产功能齐全的蛋白质。对mRNA质量控制途径的未来见解将使我们能够了解如何控制细胞mRNA水平，如何消除有缺陷或不需要的mRNA，以及这些失调如何导致人类疾病。在这里，我们回顾翻译偶联mRNA质量控制机制，包括不停止和不停止的mRNA衰变途径，描述它们的机制，共享的交易因素，和差异。我们还描述了我们对无义介导的mRNA衰变（NMD）途径的理解的进展，强调最近的机械发现，新因素的发现，以及NMD在细胞生理学中的作用及其对人类疾病的影响。
