PDF(Pubmed)
Abstract：
Recent advances in methods to culture pluripotent stem cells to model human development have resulted in entities that increasingly have recapitulated advanced stages of early embryo development. These entities, referred to by numerous terms such as embryoids, are becoming more sophisticated and could resemble human embryos ever more closely as research progresses. This paper reports a systematic review of the ethical, legal, regulatory, and policy questions and concerns found in the literature concerning human embryoid research published from 2016 to 2022. We identified 56 papers that use 53 distinct names or terms to refer to embryoids and four broad categories of ethical, legal, regulatory, or policy considerations in the literature: research justifications/benefits, ethical significance or moral status, permissible use, and regulatory and oversight challenges. Analyzing the full range of issues is a critical step toward fostering more robust ethical, legal, and social implications research in this emerging area and toward developing appropriate oversight.
摘要：
培养多能干细胞以模拟人类发育的方法的最新进展已经导致越来越多地概述早期胚胎发育的晚期阶段的实体。这些实体,被许多术语称为，如胚状体，随着研究的进展，它们变得越来越复杂，可能越来越像人类胚胎。本文报道了对伦理的系统回顾，legal,监管,以及2016年至2022年发表的有关人类胚状体研究的文献中发现的政策问题和担忧。我们确定了56篇论文，这些论文使用53个不同的名称或术语来指代胚状体和四大类伦理学，legal,监管,或文献中的政策考虑：研究理由/好处，伦理意义或道德地位，允许使用,以及监管和监督方面的挑战。分析所有问题是培养更强大的道德的关键一步，legal,以及这一新兴领域的社会影响研究，并朝着发展适当的监督方向发展。
