PDF(Pubmed)
Abstract：
Glucose-Regulated Protein 78 (GRP78) is a chaperone protein that is predominantly expressed in the lumen of the endoplasmic reticulum. GRP78 plays a crucial role in protein folding by assisting in the assembly of misfolded proteins. Under cellular stress conditions, GRP78 can translocate to the cell surface (csGRP78) were it interacts with different ligands to initiate various intracellular pathways. The expression of csGRP78 has been associated with tumor initiation and progression of multiple cancer types. This review provides a comprehensive analysis of the existing evidence on the roles of GRP78 in various types of cancer and other human pathology. Additionally, the review discusses the current understanding of the mechanisms underlying GRP78\'s involvement in tumorigenesis and cancer advancement. Furthermore, we highlight recent innovative approaches employed in downregulating GRP78 expression in cancers as a potential therapeutic target.
摘要：
葡萄糖调节蛋白78(GRP78)是主要在内质网的内腔中表达的伴奏蛋白。GRP78通过协助错误折叠蛋白质的组装在蛋白质折叠中起关键作用。在细胞应激条件下，GRP78可以易位到细胞表面（csGRP78），它与不同的配体相互作用，以启动各种细胞内途径。csGRP78的表达与多种癌症类型的肿瘤起始和进展有关。这篇综述提供了关于GRP78在各种类型的癌症和其他人类病理中的作用的现有证据的全面分析。此外,这篇综述讨论了目前对GRP78参与肿瘤发生和癌症进展的潜在机制的理解.此外，我们重点介绍了最近用于下调癌症中GRP78表达的创新方法作为潜在的治疗靶点.
