PDF(Pubmed)
Abstract：
OBJECTIVE: The aim is to determine the magnitude of glaucomatous damage in the asymptomatic subjects identified with primary glaucoma for the first time and thus to evaluate the significance and efficacy of screening measures for glaucoma.
METHODS: An observational retrospective cohort study of 100 asymptomatic patients of age more than 40 years, diagnosed with and under treatment for primary glaucoma was performed. Patients were categorized into having early, moderate, and severe glaucoma, according to standard automated perimetry (SAP) mean deviation (MD) in the worse eye (<-6, -6 to -12 and >-12 dB, respectively). Risk factors were correlated with the severity of glaucoma at presentation and statistically analyzed.
RESULTS: About 32%, 33%, and 35% of patients were found to have early, moderate, and severe stages of glaucoma with average MD of -3.51 ±1.53, -8.65 ±1.64, -17.15 ± 5.13 on SAP, respectively. The association of risk factors such as age (P = 0.006) and glaucoma awareness (P = 0.044) with the severity of glaucoma was statistically significant. There was no direct statistical correlation found between gender, history of diabetes mellitus, family history of glaucoma, intraocular pressure, central corneal thickness, the angle width, and the severity of glaucoma in our study.
CONCLUSIONS: Majority of cases with primary glaucoma show no symptoms until advanced irreversible stages. Early screening and proper treatment are the only ways to halt its progression. In spite of available facilities, 68% of patients in our study were found to have moderate-to-severe stages of glaucoma. This indicates that our screening measures should reach the masses at the primary level, with a focus on awareness programs.
METHODS: An observational retrospective cohort study of 100 asymptomatic patients of age more than 40 years, diagnosed with and under treatment for primary glaucoma was performed. Patients were categorized into having early, moderate, and severe glaucoma, according to standard automated perimetry (SAP) mean deviation (MD) in the worse eye (<-6, -6 to -12 and >-12 dB, respectively). Risk factors were correlated with the severity of glaucoma at presentation and statistically analyzed.
RESULTS: About 32%, 33%, and 35% of patients were found to have early, moderate, and severe stages of glaucoma with average MD of -3.51 ±1.53, -8.65 ±1.64, -17.15 ± 5.13 on SAP, respectively. The association of risk factors such as age (P = 0.006) and glaucoma awareness (P = 0.044) with the severity of glaucoma was statistically significant. There was no direct statistical correlation found between gender, history of diabetes mellitus, family history of glaucoma, intraocular pressure, central corneal thickness, the angle width, and the severity of glaucoma in our study.
CONCLUSIONS: Majority of cases with primary glaucoma show no symptoms until advanced irreversible stages. Early screening and proper treatment are the only ways to halt its progression. In spite of available facilities, 68% of patients in our study were found to have moderate-to-severe stages of glaucoma. This indicates that our screening measures should reach the masses at the primary level, with a focus on awareness programs.
摘要：
目的：目的是确定首次发现原发性青光眼的无症状受试者的青光眼损害程度，从而评估青光眼筛查措施的意义和有效性。
方法：对100名年龄超过40岁的无症状患者进行观察性回顾性队列研究，诊断为原发性青光眼并接受治疗。患者被归类为早期，中度,严重的青光眼,根据标准自动视野检查（SAP）的平均偏差（MD），较差的眼睛（<-6，-6至-12和>-12dB，分别)。危险因素与青光眼的严重程度相关，并进行统计学分析。
结果：大约32%，33%,35%的患者被发现早期，中度,和严重的青光眼阶段，SAP的平均MD为-3.51±1.53，-8.65±1.64，-17.15±5.13，分别。年龄(P=0.006)、青光眼知晓率(P=0.044)等危险因素与青光眼严重程度有统计学意义。性别之间没有直接的统计相关性，糖尿病史，青光眼家族史,眼内压,中央角膜厚度,角度宽度，以及我们研究中青光眼的严重程度。
结论：大多数原发性青光眼患者直到晚期不可逆阶段才表现出症状。早期筛查和适当治疗是阻止其进展的唯一方法。尽管有可用的设施，在我们的研究中，有68％的患者被发现患有中度至重度青光眼。这表明我们的甄别措施要深入群众基层,专注于意识计划。
方法：对100名年龄超过40岁的无症状患者进行观察性回顾性队列研究，诊断为原发性青光眼并接受治疗。患者被归类为早期，中度,严重的青光眼,根据标准自动视野检查（SAP）的平均偏差（MD），较差的眼睛（<-6，-6至-12和>-12dB，分别)。危险因素与青光眼的严重程度相关，并进行统计学分析。
结果：大约32%，33%,35%的患者被发现早期，中度,和严重的青光眼阶段，SAP的平均MD为-3.51±1.53，-8.65±1.64，-17.15±5.13，分别。年龄(P=0.006)、青光眼知晓率(P=0.044)等危险因素与青光眼严重程度有统计学意义。性别之间没有直接的统计相关性，糖尿病史，青光眼家族史,眼内压,中央角膜厚度,角度宽度，以及我们研究中青光眼的严重程度。
结论：大多数原发性青光眼患者直到晚期不可逆阶段才表现出症状。早期筛查和适当治疗是阻止其进展的唯一方法。尽管有可用的设施，在我们的研究中，有68％的患者被发现患有中度至重度青光眼。这表明我们的甄别措施要深入群众基层,专注于意识计划。
