Haploidentical hematopoietic cell transplant recipient presents with late-onset Epstein Barr virus-associated posttransplant lymphoproliferative disorder.

单倍体相合造血细胞移植受者出现迟发性 EB 病毒相关移植后淋巴增殖性疾病

• 发表时间: 2023 Aug
• 来源期刊: EJHaem
• DOI: 10.1002/jha2.707
• PMID: 37601848
• 文章类型: Case Reports
• 作者列表: Braun A,Liu L,Al Malki MM,Becker PS

关键词: PTCy; ebstein barr virus; haploidentical; hematopoietic stem cell transplant; leukemia; post transplant lymphoproliferative disorder

Abstract

Posttransplant lymphoproliferative disease (PTLD) is a potentially life-threatening complication of hematopoietic cell transplantation. With improvements in Epstein-Barr virus (EBV) monitoring and supportive care, PTLD incidence has decreased throughout the history of bone marrow transplantation. It is rare to develop PTLD after the first year following transplant, across all donor categories. In this case, we hope to elucidate details that may have predisposed to this unusual presentation. We present the case of a 55-year-old gentleman with acute myeloid leukemia who underwent a haploidentical transplant for consolidation and presented with fatigue, lethargy and presumed septic shock nearly 7 years after transplant.

摘要

移植后淋巴增殖性疾病（PTLD）是造血细胞移植的潜在威胁生命的并发症。随着爱泼斯坦-巴尔病毒（EBV）监测和支持治疗的改善，在整个骨髓移植的历史中，PTLD的发生率一直在下降。在移植后的第一年后发展PTLD是罕见的，所有捐赠者类别。在这种情况下,我们希望阐明可能导致这种不寻常的演讲的细节。我们介绍了一名55岁的急性髓细胞性白血病绅士的病例，他接受了单倍体移植以巩固并表现出疲劳，移植后近7年的嗜睡和感染性休克。