PDF(Pubmed)
Abstract：
UNASSIGNED: Tracheobronchopathia osteochondroplastica (TO) is a relatively rare benign tracheobronchial disease, which is often misdiagnosed or missed. To date, there is no specific treatment for TO. The aim of this study was to investigate the clinical manifestations, imaging features, bronchoscopy results, pathological findings, and diagnostic points of TO.
UNASSIGNED: A total of 33 patients diagnosed with TO were enrolled. Clinical data were collected using retrospective methods in the period from January 2021 and November 2022. Descriptive analysis was used.
UNASSIGNED: Patients included 17 (51.5%) male and 16 (48.5%) female, with a median age of 54 years. The main clinical manifestations included cough in 15 cases, fever in 6 cases, chest tightness in 4 cases, haemoptysis in 3 cases, and chest pain in 4 cases. The time from the onset of symptoms to diagnosis was 1 week to 96 months. Some patients were diagnosed with other lung diseases, including 16 patients with tuberculosis, 2 patients with lung cancer, 3 patients with nontuberculous mycobacteriosis, 3 patients with tuberculous pleurisy, 2 patients with bronchiectasis, and 1 patient with pneumonia. Chest computed tomography (CT) scan demonstrated calcified nodules in 10 (30.3%) patients. In bronchoscopy, entire tracheal involvement was found in 21 (63.6%) patients, 12 (36.4%) patients were found to have involvement of only part of the trachea. The patients were divided into three groups according to the bronchoscopic presentation, the largest proportion was stage II (19/33), followed by stage I (8/33) and stage III (6/33). Histopathological findings showed squamous metaplasia, cartilaginous, and bony tissues.
UNASSIGNED: TO is a slowly progressing disease with non-specific clinical symptoms and a low positive rate of imaging diagnosis, making it susceptible to misdiagnosis and missed diagnosis. The disease needs to be diagnosed by combining imaging features, fiberoptic bronchoscopy, and pathological findings.
UNASSIGNED: A total of 33 patients diagnosed with TO were enrolled. Clinical data were collected using retrospective methods in the period from January 2021 and November 2022. Descriptive analysis was used.
UNASSIGNED: Patients included 17 (51.5%) male and 16 (48.5%) female, with a median age of 54 years. The main clinical manifestations included cough in 15 cases, fever in 6 cases, chest tightness in 4 cases, haemoptysis in 3 cases, and chest pain in 4 cases. The time from the onset of symptoms to diagnosis was 1 week to 96 months. Some patients were diagnosed with other lung diseases, including 16 patients with tuberculosis, 2 patients with lung cancer, 3 patients with nontuberculous mycobacteriosis, 3 patients with tuberculous pleurisy, 2 patients with bronchiectasis, and 1 patient with pneumonia. Chest computed tomography (CT) scan demonstrated calcified nodules in 10 (30.3%) patients. In bronchoscopy, entire tracheal involvement was found in 21 (63.6%) patients, 12 (36.4%) patients were found to have involvement of only part of the trachea. The patients were divided into three groups according to the bronchoscopic presentation, the largest proportion was stage II (19/33), followed by stage I (8/33) and stage III (6/33). Histopathological findings showed squamous metaplasia, cartilaginous, and bony tissues.
UNASSIGNED: TO is a slowly progressing disease with non-specific clinical symptoms and a low positive rate of imaging diagnosis, making it susceptible to misdiagnosis and missed diagnosis. The disease needs to be diagnosed by combining imaging features, fiberoptic bronchoscopy, and pathological findings.
摘要：
■气管支气管病骨软骨病（TO）是一种相对罕见的良性气管支气管疾病，经常被误诊或漏诊。迄今为止,TO没有具体的治疗方法。这项研究的目的是探讨临床表现，成像特征,支气管镜检查结果，病理结果，和TO的诊断要点。
■共纳入33例诊断为TO的患者。使用回顾性方法收集2021年1月至2022年11月期间的临床数据。使用描述性分析。
■患者包括17名（51.5%）男性和16名（48.5%）女性，平均年龄为54岁。主要临床表现为咳嗽15例,6例发热,4例胸闷，咯血3例,胸痛4例。从症状发作到诊断的时间为1周至96个月。一些患者被诊断出患有其他肺部疾病，包括16名肺结核患者，2名肺癌患者，3例非结核性分枝杆菌病，3例结核性胸膜炎，2例支气管扩张患者，1例肺炎患者。胸部计算机断层扫描（CT）扫描显示10例（30.3％）患者的钙化结节。在支气管镜检查中，21例(63.6%)患者发现气管受累，发现12例（36.4％）患者仅部分气管受累。根据支气管镜表现将患者分为三组，比例最大的是第二阶段(19/33)，然后是第一阶段（8/33）和第三阶段（6/33）。组织病理学表现为鳞状上皮化生,软骨，和骨组织。
■TO是一种进展缓慢的疾病，具有非特异性临床症状，影像学诊断阳性率低，容易误诊和漏诊。这种疾病需要结合影像学特征进行诊断，纤维支气管镜检查，和病理结果。
■共纳入33例诊断为TO的患者。使用回顾性方法收集2021年1月至2022年11月期间的临床数据。使用描述性分析。
■患者包括17名（51.5%）男性和16名（48.5%）女性，平均年龄为54岁。主要临床表现为咳嗽15例,6例发热,4例胸闷，咯血3例,胸痛4例。从症状发作到诊断的时间为1周至96个月。一些患者被诊断出患有其他肺部疾病，包括16名肺结核患者，2名肺癌患者，3例非结核性分枝杆菌病，3例结核性胸膜炎，2例支气管扩张患者，1例肺炎患者。胸部计算机断层扫描（CT）扫描显示10例（30.3％）患者的钙化结节。在支气管镜检查中，21例(63.6%)患者发现气管受累，发现12例（36.4％）患者仅部分气管受累。根据支气管镜表现将患者分为三组，比例最大的是第二阶段(19/33)，然后是第一阶段（8/33）和第三阶段（6/33）。组织病理学表现为鳞状上皮化生,软骨，和骨组织。
■TO是一种进展缓慢的疾病，具有非特异性临床症状，影像学诊断阳性率低，容易误诊和漏诊。这种疾病需要结合影像学特征进行诊断，纤维支气管镜检查，和病理结果。
