PDF(Pubmed)
Abstract：
Desmoid tumor (DT) is a rare neoplasm characterized by the proliferation of myofibroblastic cells that infiltrates and invades adjacent tissues. Due to its locally aggressive and recurrent nature, DT often causes local symptoms and can be challenging to manage clinically. Therefore, identifying biomarkers that can predict the progression of DT and guide treatment decisions is critical. This review summarizes several biomarkers that have been implicated in active surveillance (AS) and the prediction of postoperative recurrence and attempts to elucidate their underlying mechanisms. Some of these novel markers could provide prognostic value for clinicians, and ultimately help facilitate optimal and accurate therapeutic decisions for DT.
摘要：
纤维瘤（DT）是一种罕见的肿瘤，其特征是肌纤维母细胞的增殖，浸润并侵入邻近组织。由于其局部侵略性和复发性，DT通常会引起局部症状，并且在临床上处理可能具有挑战性。因此,识别能够预测DT进展和指导治疗决策的生物标志物至关重要.这篇综述总结了与主动监测（AS）和术后复发预测有关的几种生物标志物，并试图阐明其潜在机制。这些新标志物中的一些可以为临床医生提供预后价值，并最终帮助促进DT的最佳和准确的治疗决策。
