PDF(Pubmed)
Abstract：
Inherited metabolic disorders arise from mutations in genes involved in the biogenesis, assembly, or activity of metabolic enzymes, leading to enzymatic deficiency and severe metabolic impairments. Metabolic enzymes are essential for the normal functioning of cells and are involved in the production of amino acids, fatty acids and nucleotides, which are essential for cell growth, division and survival. When the activity of metabolic enzymes is disrupted due to mutations or changes in expression levels, it can result in various metabolic disorders that have also been linked to cancer development. However, there remains much to learn regarding the relationship between the dysregulation of metabolic enzymes and metabolic adaptations in cancer cells. In this review, we explore how dysregulated metabolism due to the alteration or change of metabolic enzymes in cancer cells plays a crucial role in tumor development, progression, metastasis and drug resistance. In addition, these changes in metabolism provide cancer cells with a number of advantages, including increased proliferation, resistance to apoptosis and the ability to evade the immune system. The tumor microenvironment, genetic context, and different signaling pathways further influence this interplay between cancer and metabolism. This review aims to explore how the dysregulation of metabolic enzymes in specific pathways, including the urea cycle, glycogen storage, lysosome storage, fatty acid oxidation, and mitochondrial respiration, contributes to the development of metabolic disorders and cancer. Additionally, the review seeks to shed light on why these enzymes represent crucial potential therapeutic targets and biomarkers in various cancer types.
摘要：
遗传性代谢紊乱是由参与生物发生的基因突变引起的。装配,或代谢酶的活性，导致酶缺乏和严重的代谢障碍。代谢酶对于细胞的正常功能是必不可少的，并且参与氨基酸的产生，脂肪酸和核苷酸，对细胞生长至关重要，分裂与生存。当代谢酶的活性由于突变或表达水平的变化而被破坏时，它可以导致各种代谢紊乱，这些代谢紊乱也与癌症的发展有关。然而,关于癌细胞中代谢酶失调与代谢适应之间的关系，还有很多需要学习的东西。在这次审查中,我们探讨了由于癌细胞中代谢酶的改变或变化而导致的代谢失调在肿瘤发展中起着至关重要的作用，programming,转移和耐药性。此外,这些新陈代谢的变化为癌细胞提供了许多优势，包括增加扩散，抵抗细胞凋亡和逃避免疫系统的能力。肿瘤微环境,遗传背景，和不同的信号通路进一步影响癌症和代谢之间的相互作用。本文旨在探讨代谢酶在特定通路中的失调,包括尿素循环，糖原储存，溶酶体贮存,脂肪酸氧化，和线粒体呼吸，有助于代谢紊乱和癌症的发展。此外,这篇综述试图阐明为什么这些酶是各种癌症中关键的潜在治疗靶点和生物标志物.
