PDF(Pubmed)
Abstract：
E-boxes are important regulatory elements in the eukaryotic genome. Transcription factors can bind to E-boxes through their basic helix-loop-helix or zinc finger domain to regulate gene transcription. E-box-binding transcription factors (EBTFs) are important regulators of development and essential for physiological activities of the cell. The fundamental role of EBTFs in cancer has been highlighted by studies on the canonical oncogene MYC, yet many EBTFs exhibit common features, implying the existence of shared molecular principles of how they are involved in tumorigenesis. A comprehensive analysis of TFs that share the basic function of binding to E-boxes has been lacking. Here, we review the structure of EBTFs, their common features in regulating transcription, their physiological functions, and their mutual regulation. We also discuss their converging functions in cancer biology, their potential to be targeted as a regulatory network, and recent progress in drug development targeting these factors in cancer therapy.
摘要：
E盒是真核生物基因组中重要的调控元件。转录因子可以通过其基本螺旋-环-螺旋或锌指结构域与E-box结合以调节基因转录。E盒结合转录因子(EBTFs)是细胞发育的重要调控因子,是细胞生理活动的重要调控因子。关于经典癌基因MYC的研究强调了EBTFs在癌症中的基本作用，然而，许多EBTFs表现出共同的特征，暗示着它们如何参与肿瘤发生的共同分子原理的存在。一直缺乏对共享绑定到电子盒的基本功能的TFs的全面分析。这里,我们回顾了EBTFs的结构，它们在调节转录方面的共同特征，它们的生理功能，和他们的相互调节。我们还讨论了它们在癌症生物学中的融合功能，他们有可能成为监管网络的目标，以及在癌症治疗中针对这些因素的药物开发的最新进展。
