关键词: JIA epidemiology inflammation pregnancy and rheumatic disease

来  源:   DOI:10.1093/rap/rkad062   PDF(Pubmed)

Abstract:
UNASSIGNED: The literature on delivery methods in women with JIA is limited. Active inflammation is a risk factor for caesarean section (CS) in other arthritic diseases. A CS entails a higher risk for complications than vaginal delivery and restricted physical activity in the first weeks after birth. Our objective was to explore a possible association of inflammatory active disease and the proportion of CS in women with JIA.
UNASSIGNED: Data from the Norwegian nationwide observational register RevNatus were linked with data from the Medical Birth Registry of Norway (MBRN). Cases comprised singleton births in women with JIA (n = 196) included in RevNatus from 2010 to 2019. Singleton births registered in the MBRN during the same period of time, excluding births in mothers with rheumatic inflammatory diseases, served as population controls (n = 575 798).
UNASSIGNED: CS was more frequent in women with JIA (20.4%) and in the subgroup of women with inflammatory active JIA (30.0%) than in population controls (15.6%). Women with active JIA had a risk for elective CS similar to population controls [risk difference 2.3% (95% CI -2.5, 12.9)] and a higher risk for emergency CS [risk difference 14.0% (95% CI 4.3, 27.4)] compared with population controls.
UNASSIGNED: Women with active JIA had a higher risk for emergency CS, but not elective CS, compared with population controls.
摘要:
关于JIA女性分娩方法的文献有限。在其他关节炎疾病中,活动性炎症是剖腹产(CS)的危险因素。在出生后的头几周,CS比阴道分娩和限制体力活动带来更高的并发症风险。我们的目的是探讨JIA女性中炎性活动性疾病和CS比例的可能关联。
来自挪威全国范围的观察登记册RevNatus的数据与来自挪威医学出生登记处(MBRN)的数据相关联。病例包括2010年至2019年RevNatus中JIA妇女的单胎分娩(n=196)。同一时期在MBRN登记的单胎出生,不包括患有风湿性炎症性疾病的母亲的分娩,作为人口对照(n=575798)。
CS在JIA女性(20.4%)和炎症活动性JIA女性亚组(30.0%)中的频率高于人群对照组(15.6%)。与人口对照组相比,活跃JIA的女性有类似的选择性CS风险[风险差异2.3%(95%CI-2.5,12.9)]和更高的急诊CS风险[风险差异14.0%(95%CI4.3,27.4)]。
JIA活跃的女性患紧急CS的风险更高,但不是选修CS,与人口对照相比。
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