PDF(Pubmed)
Abstract：
UNASSIGNED: To report a novel technique to facilitate amniotic membrane transplantation (AMT) for acute stage Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN).
UNASSIGNED: Laboratory investigation and retrospective, single-center case series.
UNASSIGNED: The polylactic acid (PLA) amniotic fornical ring (AFR) have been successfully manufactured by three-dimensional (3D) printing technology for AMT. This study retrospectively analyzed the medical records of 5 SJS/TEN patients at the acute stage between 2019 and 2023. Patients were surgically treated with AFR or sutured amniotic membrane transplant (SAMT). Epidemiology, best-corrected visual acuity (BCVA), acute ocular severity score, operative duration, epithelial healing time, amniotic dissolution and follow-up time were evaluated.
UNASSIGNED: Of all five patients, three patients (6 eyes) received AFR/AMT (Group A), and 2 patients (4 eyes) received SAMT (Group B). There were no significant differences between two groups in the mean preoperative days and vision changes. The mean operation duration was 11.7 ± 3.8 mins in group A. Compared with the SAMT (48.8 ± 5.3 mins), the operation duration was reduced by 76.02%. The mean times for epithelial healing were 32.5 ± 29.2 days in group A and 12.0 ± 0.0 days in group B. In addition, there were no significant side effects of 3D-printed sterile AFR on the eyes.
UNASSIGNED: 3D-printed PLA scaffolds could be used as an AFR device for acute SJS/TEN. In addition, personalized 3D-printed AFR is superior to conventional SAMT in operation duration.
UNASSIGNED: Laboratory investigation and retrospective, single-center case series.
UNASSIGNED: The polylactic acid (PLA) amniotic fornical ring (AFR) have been successfully manufactured by three-dimensional (3D) printing technology for AMT. This study retrospectively analyzed the medical records of 5 SJS/TEN patients at the acute stage between 2019 and 2023. Patients were surgically treated with AFR or sutured amniotic membrane transplant (SAMT). Epidemiology, best-corrected visual acuity (BCVA), acute ocular severity score, operative duration, epithelial healing time, amniotic dissolution and follow-up time were evaluated.
UNASSIGNED: Of all five patients, three patients (6 eyes) received AFR/AMT (Group A), and 2 patients (4 eyes) received SAMT (Group B). There were no significant differences between two groups in the mean preoperative days and vision changes. The mean operation duration was 11.7 ± 3.8 mins in group A. Compared with the SAMT (48.8 ± 5.3 mins), the operation duration was reduced by 76.02%. The mean times for epithelial healing were 32.5 ± 29.2 days in group A and 12.0 ± 0.0 days in group B. In addition, there were no significant side effects of 3D-printed sterile AFR on the eyes.
UNASSIGNED: 3D-printed PLA scaffolds could be used as an AFR device for acute SJS/TEN. In addition, personalized 3D-printed AFR is superior to conventional SAMT in operation duration.
摘要：
■报告一种促进羊膜移植（AMT）治疗急性期史蒂文斯-约翰逊综合征（SJS）和中毒性表皮坏死松解症（TEN）的新技术。
■实验室调查和回顾性研究，单中心案例系列。
■聚乳酸（PLA）羊膜孔环（AFR）已通过用于AMT的三维（3D）打印技术成功制造。本研究回顾性分析了5例SJS/TEN患者在2019年至2023年急性期的病历。患者接受AFR或缝合羊膜移植（SAMT）手术治疗。流行病学,最佳矫正视力（BCVA），急性眼部严重程度评分，手术持续时间,上皮愈合时间,评估羊膜溶解和随访时间。
■在所有五名患者中，3例患者（6只眼）接受AFR/AMT（A组），2例(4只眼)接受SAMT(B组)。两组的术前平均天数和视力变化没有显着差异。A组平均手术时间为11.7±3.8min,与SAMT(48.8±5.3min)比较,手术时间缩短了76.02%。平均上皮愈合时间A组为32.5±29.2天,B组为12.0±0.0天,3D打印无菌AFR对眼睛没有明显的副作用。
■3D打印的PLA支架可用作急性SJS/TEN的AFR装置。此外,个性化3D打印AFR在手术持续时间上优于传统SAMT。
■实验室调查和回顾性研究，单中心案例系列。
■聚乳酸（PLA）羊膜孔环（AFR）已通过用于AMT的三维（3D）打印技术成功制造。本研究回顾性分析了5例SJS/TEN患者在2019年至2023年急性期的病历。患者接受AFR或缝合羊膜移植（SAMT）手术治疗。流行病学,最佳矫正视力（BCVA），急性眼部严重程度评分，手术持续时间,上皮愈合时间,评估羊膜溶解和随访时间。
■在所有五名患者中，3例患者（6只眼）接受AFR/AMT（A组），2例(4只眼)接受SAMT(B组)。两组的术前平均天数和视力变化没有显着差异。A组平均手术时间为11.7±3.8min,与SAMT(48.8±5.3min)比较,手术时间缩短了76.02%。平均上皮愈合时间A组为32.5±29.2天,B组为12.0±0.0天,3D打印无菌AFR对眼睛没有明显的副作用。
■3D打印的PLA支架可用作急性SJS/TEN的AFR装置。此外,个性化3D打印AFR在手术持续时间上优于传统SAMT。
